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SLAM-family receptors promote resolution of ILC2-mediated inflammation

Author

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  • Yuande Wang

    (the First Affiliated Hospital of Anhui Medical University and Institute of Clinical Immunology, Anhui Medical University
    Tsinghua University)

  • Yuhe Quan

    (Tsinghua University)

  • Junming He

    (Tsinghua University)

  • Shasha Chen

    (the First Affiliated Hospital of Anhui Medical University and Institute of Clinical Immunology, Anhui Medical University
    Innovative Institute of Tumor Immunity and Medicine (ITIM)
    Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy
    Anhui Medical University)

  • Zhongjun Dong

    (the First Affiliated Hospital of Anhui Medical University and Institute of Clinical Immunology, Anhui Medical University
    Tsinghua University
    Innovative Institute of Tumor Immunity and Medicine (ITIM)
    Anhui Province Key Laboratory of Tumor Immune Microenvironment and Immunotherapy)

Abstract

Type 2 innate lymphoid cells (ILC2) initiate early allergic inflammation in the lung, but the factors that promote subsequent resolution of type 2 inflammation and prevent prolonged ILC2 activation are not fully known. Here we show that SLAM-family receptors (SFR) play essential roles in this process. We demonstrate dynamic expression of several SFRs on ILC2s during papain-induced type 2 immunity in mice. SFR deficiency exacerbates ILC2-driven eosinophil infiltration in the lung, and results in a significant increase in IL-13 production by ILC2s exclusively in mediastinal lymph nodes (MLN), leading to increased dendritic cell (DC) and TH2 cell numbers. In MLNs, we observe more frequent interaction between ILC2s and bystander T cells, with T cell-expressed SFRs (especially SLAMF3 and SLAMF5) acting as self-ligands to suppress IL-13 production by ILC2s. Mechanistically, homotypic engagement of SFRs at the interface between ILC2s and T cells delivers inhibitory signaling primarily mediated by SHIP-1. This prevents activation of NF-κB, driven by IL-7 and IL-33, two major drivers of ILC2-mediated type 2 immunity. Thus, our study shows that an ILC2-DC-TH2 regulatory axis may promote the resolution of pulmonary type 2 immune responses, and highlights SLAMF3/SLAMF5 as potential therapeutic targets for ameliorating type 2 immunity.

Suggested Citation

  • Yuande Wang & Yuhe Quan & Junming He & Shasha Chen & Zhongjun Dong, 2024. "SLAM-family receptors promote resolution of ILC2-mediated inflammation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-49466-9
    DOI: 10.1038/s41467-024-49466-9
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