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Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis

Author

Listed:
  • Sara Trabanelli

    (University of Lausanne)

  • Mathieu F. Chevalier

    (Lausanne University Hospital (CHUV))

  • Amaia Martinez-Usatorre

    (University of Lausanne)

  • Alejandra Gomez-Cadena

    (University of Lausanne)

  • Bérengère Salomé

    (University of Lausanne)

  • Mariangela Lecciso

    (University of Bologna)

  • Valentina Salvestrini

    (University of Bologna)

  • Grégory Verdeil

    (University of Lausanne)

  • Julien Racle

    (University of Lausanne
    Swiss Institute of Bioinformatics (SIB))

  • Cristina Papayannidis

    (University of Bologna)

  • Hideaki Morita

    (University of Zurich
    Christine Kühne-Center for Allergy Research and Education)

  • Irene Pizzitola

    (University of Lausanne)

  • Camille Grandclément

    (University of Lausanne)

  • Perrine Bohner

    (Lausanne University Hospital (CHUV))

  • Elena Bruni

    (University of Milan
    Humanitas Clinical and Research Center)

  • Mukul Girotra

    (University of Lausanne)

  • Rani Pallavi

    (European Institute of Oncology)

  • Paolo Falvo

    (European Institute of Oncology)

  • Elisabeth Oppliger Leibundgut

    (Bern University Hospital, University of Bern)

  • Gabriela M. Baerlocher

    (Bern University Hospital, University of Bern)

  • Carmelo Carlo-Stella

    (Humanitas Clinical and Research Center
    Humanitas University)

  • Daniela Taurino

    (Humanitas Clinical and Research Center
    Humanitas University)

  • Armando Santoro

    (Humanitas Clinical and Research Center
    Humanitas University)

  • Orietta Spinelli

    (Ospedale Papa Giovanni XXIII)

  • Alessandro Rambaldi

    (Ospedale Papa Giovanni XXIII
    Università Statale di Milano)

  • Emanuela Giarin

    (University of Padova)

  • Giuseppe Basso

    (University of Padova)

  • Cristina Tresoldi

    (San Raffaele Hospital)

  • Fabio Ciceri

    (San Raffaele Hospital)

  • David Gfeller

    (University of Lausanne
    Swiss Institute of Bioinformatics (SIB))

  • Cezmi A. Akdis

    (University of Zurich)

  • Luca Mazzarella

    (European Institute of Oncology
    European Institute of Oncology)

  • Saverio Minucci

    (European Institute of Oncology)

  • Pier Giuseppe Pelicci

    (European Institute of Oncology)

  • Emanuela Marcenaro

    (University of Genoa)

  • Andrew N. J. McKenzie

    (MRC Laboratory of Molecular Biology)

  • Dominique Vanhecke

    (University of Lausanne)

  • George Coukos

    (University of Lausanne)

  • Domenico Mavilio

    (University of Milan
    Humanitas Clinical and Research Center)

  • Antonio Curti

    (University of Bologna)

  • Laurent Derré

    (Lausanne University Hospital (CHUV))

  • Camilla Jandus

    (University of Lausanne)

Abstract

Group 2 innate lymphoid cells (ILC2s) are involved in human diseases, such as allergy, atopic dermatitis and nasal polyposis, but their function in human cancer remains unclear. Here we show that, in acute promyelocytic leukaemia (APL), ILC2s are increased and hyper-activated through the interaction of CRTH2 and NKp30 with elevated tumour-derived PGD2 and B7H6, respectively. ILC2s, in turn, activate monocytic myeloid-derived suppressor cells (M-MDSCs) via IL-13 secretion. Upon treating APL with all-trans retinoic acid and achieving complete remission, the levels of PGD2, NKp30, ILC2s, IL-13 and M-MDSCs are restored. Similarly, disruption of this tumour immunosuppressive axis by specifically blocking PGD2, IL-13 and NKp30 partially restores ILC2 and M-MDSC levels and results in increased survival. Thus, using APL as a model, we uncover a tolerogenic pathway that may represent a relevant immunosuppressive, therapeutic targetable, mechanism operating in various human tumour types, as supported by our observations in prostate cancer.

Suggested Citation

  • Sara Trabanelli & Mathieu F. Chevalier & Amaia Martinez-Usatorre & Alejandra Gomez-Cadena & Bérengère Salomé & Mariangela Lecciso & Valentina Salvestrini & Grégory Verdeil & Julien Racle & Cristina Pa, 2017. "Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis," Nature Communications, Nature, vol. 8(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:8:y:2017:i:1:d:10.1038_s41467-017-00678-2
    DOI: 10.1038/s41467-017-00678-2
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    Cited by:

    1. Yuande Wang & Yuhe Quan & Junming He & Shasha Chen & Zhongjun Dong, 2024. "SLAM-family receptors promote resolution of ILC2-mediated inflammation," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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