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Re-Formulated Immuno-Editing as Agonist and Permissive Elements in Establishment of Foci of Carcinogenesis

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  • Lawrence M Agius

    (Department of Pathology, University of Malta Medical School, Malta)

Abstract

Diffusional phenomena of paracrine and autocrine reconstitution in a focus of initial carcinogenesis include the derivative phenomenon of immuno-editing in the induced loss of immuno-surveillance. Immuno-surveillance is attempted definition of the constitutional identification of an injury that relates intimately with inflammatory response and interactivity. In terms further conforming to an injury in chronic inflammation, the responsive elements at reconstitution fail as a result of loss an antigenicity of individual tumor cells. Recapitulation of such agonist action is further promoted as permissive elemental injury that transforms such permissiveness to the emergence of tumor cells that evade the immune system. Characterization is injury-provoking within the systems of complex interactivity as modulated by multiple molecular events at attempted reconstitution.

Suggested Citation

  • Lawrence M Agius, 2019. "Re-Formulated Immuno-Editing as Agonist and Permissive Elements in Establishment of Foci of Carcinogenesis," Cancer Therapy & Oncology International Journal, Juniper Publishers Inc., vol. 14(1), pages 3-5, May.
    • Handle: RePEc:adp:jctoij:v:14:y:2019:i:1:p:3-5
    DOI: 10.19080/CTOIJ.2019.14.555877
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    References listed on IDEAS

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    1. Martin W. LaFleur & Thao H. Nguyen & Matthew A. Coxe & Kathleen B. Yates & Justin D. Trombley & Sarah A. Weiss & Flavian D. Brown & Jacob E. Gillis & Daniel J. Coxe & John G. Doench & W. Nicholas Hain, 2019. "A CRISPR-Cas9 delivery system for in vivo screening of genes in the immune system," Nature Communications, Nature, vol. 10(1), pages 1-10, December.
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