Priming with LSD1 inhibitors promotes the persistence and antitumor effect of adoptively transferred T cells
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DOI: 10.1038/s41467-024-48607-4
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- Cheng Zeng & Jiwei Chen & Emmalee W. Cooke & Arijita Subuddhi & Eliana T. Roodman & Fei Xavier Chen & Kaixiang Cao, 2023. "Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
- Carlson Tsui & Lorenz Kretschmer & Svenja Rapelius & Sarah S. Gabriel & David Chisanga & Konrad Knöpper & Daniel T. Utzschneider & Simone Nüssing & Yang Liao & Teisha Mason & Santiago Valle Torres & S, 2022. "MYB orchestrates T cell exhaustion and response to checkpoint inhibition," Nature, Nature, vol. 609(7926), pages 354-360, September.
- Nayan Jain & Zeguo Zhao & Judith Feucht & Richard Koche & Archana Iyer & Anton Dobrin & Jorge Mansilla-Soto & Julie Yang & Yingqian Zhan & Michael Lopez & Gertrude Gunset & Michel Sadelain, 2023. "TET2 guards against unchecked BATF3-induced CAR T cell expansion," Nature, Nature, vol. 615(7951), pages 315-322, March.
- Yi Liu & Brian Debo & Mingfeng Li & Zhennan Shi & Wanqiang Sheng & Yang Shi, 2021. "LSD1 inhibition sustains T cell invigoration with a durable response to PD-1 blockade," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
- Yao Wang & Chuan Tong & Hanren Dai & Zhiqiang Wu & Xiao Han & Yelei Guo & Deyun Chen & Jianshu Wei & Dongdong Ti & Zongzhi Liu & Qian Mei & Xiang Li & Liang Dong & Jing Nie & Yajing Zhang & Weidong Ha, 2021. "Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming," Nature Communications, Nature, vol. 12(1), pages 1-18, December.
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- Isabella Pallavicini & Teresa Maria Frasconi & Carlotta Catozzi & Elena Ceccacci & Silvia Tiberti & Dorothee Haas & Jule Samson & Christoph Heuser-Loy & Carina B. Nava Lauson & Marta Mangione & Elisa , 2024. "LSD1 inhibition improves efficacy of adoptive T cell therapy by enhancing CD8+ T cell responsiveness," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
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