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Serological evidence of zoonotic filovirus exposure among bushmeat hunters in Guinea

Author

Listed:
  • Joseph Akoi Boré

    (Ministère de la Santé et de l’hygiène publique)

  • Joseph W. S. Timothy

    (London School of Hygiene Tropical Medicine)

  • Tom Tipton

    (University of Oxford)

  • Ifono Kekoura

    (Ministère de la Santé et de l’hygiène publique)

  • Yper Hall

    (UK Health Security Agency)

  • Grace Hood

    (University of Oxford)

  • Stephanie Longet

    (University of Oxford)

  • Kimberly Fornace

    (National University of Singapore)

  • Millimono S. Lucien

    (Ministère de la Santé et de l’hygiène publique)

  • Sarah Katarina Fehling

    (Philipps University)

  • Beatrice K. Koivogui

    (Ministère de la Santé et de l’hygiène publique)

  • Si’Ana A. Coggins

    (Uniformed Services University)

  • Eric D. Laing

    (Uniformed Services University)

  • Christopher C. Broder

    (Uniformed Services University)

  • N’ Faly Magassouba

    (Ministère de la Santé et de l’hygiène publique)

  • Thomas Strecker

    (Philipps University)

  • Jeremy Rossman

    (University of Kent)

  • Kader Konde

    (Centre for Training and Research on Priority Diseases including Malaria in Guinea)

  • Miles W. Carroll

    (University of Oxford)

Abstract

Human Ebola virus (EBOV) outbreaks caused by persistent EBOV infection raises questions on the role of zoonotic spillover in filovirus epidemiology. To characterise filovirus zoonotic exposure, we collected cross-sectional serum samples from bushmeat hunters (n = 498) in Macenta Prefecture Guinea, adjacent to the index site of the 2013 EBOV-Makona spillover event. We identified distinct immune signatures (20/498, 4.0%) to multiple EBOV antigens (GP, NP, VP40) using stepwise ELISA and Western blot analysis and, live EBOV neutralisation (5/20; 25%). Using comparative serological data from PCR-confirmed survivors of the 2013-2016 EBOV outbreak, we demonstrated that most signatures (15/20) were not plausibly explained by prior EBOV-Makona exposure. Subsequent data-driven modelling of EBOV immunological outcomes to remote-sensing environmental data also revealed consistent associations with intact closed canopy forest. Together our findings suggest exposure to other closely related filoviruses prior to the 2013-2016 West Africa epidemic and highlight future surveillance priorities.

Suggested Citation

  • Joseph Akoi Boré & Joseph W. S. Timothy & Tom Tipton & Ifono Kekoura & Yper Hall & Grace Hood & Stephanie Longet & Kimberly Fornace & Millimono S. Lucien & Sarah Katarina Fehling & Beatrice K. Koivogu, 2024. "Serological evidence of zoonotic filovirus exposure among bushmeat hunters in Guinea," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48587-5
    DOI: 10.1038/s41467-024-48587-5
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    References listed on IDEAS

    as
    1. Emma E Glennon & Freya L Jephcott & Olivier Restif & James L N Wood, 2019. "Estimating undetected Ebola spillovers," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 13(6), pages 1-10, June.
    2. Alpha Kabinet Keita & Fara R. Koundouno & Martin Faye & Ariane Düx & Julia Hinzmann & Haby Diallo & Ahidjo Ayouba & Frederic Le Marcis & Barré Soropogui & Kékoura Ifono & Moussa M. Diagne & Mamadou S., 2021. "Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks," Nature, Nature, vol. 597(7877), pages 539-543, September.
    3. Brian R. Amman & Brian H. Bird & Ibrahim A. Bakarr & James Bangura & Amy J. Schuh & Jonathan Johnny & Tara K. Sealy & Immah Conteh & Alusine H. Koroma & Ibrahim Foday & Emmanuel Amara & Abdulai A. Ban, 2020. "Isolation of Angola-like Marburg virus from Egyptian rousette bats from West Africa," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
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