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Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks

Author

Listed:
  • Alpha Kabinet Keita

    (Université de Conakry
    TransVIHMI, Montpellier University/IRD/INSERM)

  • Fara R. Koundouno

    (Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG)
    Bernhard Nocht Institute for Tropical Medicine (BNITM))

  • Martin Faye

    (Institut Pasteur de Dakar (IPD))

  • Ariane Düx

    (Robert Koch Institute (RKI))

  • Julia Hinzmann

    (Bernhard Nocht Institute for Tropical Medicine (BNITM)
    Partner Site Hamburg–Lübeck–Borstel–Riems
    UK Health Security Agency, National Infection Service, Porton Down)

  • Haby Diallo

    (Université de Conakry)

  • Ahidjo Ayouba

    (TransVIHMI, Montpellier University/IRD/INSERM)

  • Frederic Le Marcis

    (Université de Conakry
    TransVIHMI, Montpellier University/IRD/INSERM
    Ecole Nationale Supérieure de Lyon)

  • Barré Soropogui

    (Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG))

  • Kékoura Ifono

    (Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG)
    Bernhard Nocht Institute for Tropical Medicine (BNITM))

  • Moussa M. Diagne

    (Institut Pasteur de Dakar (IPD))

  • Mamadou S. Sow

    (Université de Conakry
    Hôpital National Donka, Service des Maladies Infectieuses et Tropicales)

  • Joseph A. Bore

    (Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG)
    University of Oxford)

  • Sebastien Calvignac-Spencer

    (Robert Koch Institute (RKI))

  • Nicole Vidal

    (TransVIHMI, Montpellier University/IRD/INSERM)

  • Jacob Camara

    (Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG))

  • Mamadou B. Keita

    (Institut National de Santé Publique de Guinée (INSP))

  • Annick Renevey

    (Bernhard Nocht Institute for Tropical Medicine (BNITM)
    Partner Site Hamburg–Lübeck–Borstel–Riems)

  • Amadou Diallo

    (Institut Pasteur de Dakar (IPD))

  • Abdoul K. Soumah

    (Université de Conakry)

  • Saa L. Millimono

    (Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG)
    Bernhard Nocht Institute for Tropical Medicine (BNITM))

  • Almudena Mari-Saez

    (Robert Koch Institute (RKI))

  • Mamadou Diop

    (Institut Pasteur de Dakar (IPD))

  • Ahmadou Doré

    (Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG))

  • Fodé Y. Soumah

    (Hôpital National Donka, Service des Maladies Infectieuses et Tropicales)

  • Kaka Kourouma

    (Institut National de Santé Publique de Guinée (INSP))

  • Nathalie J. Vielle

    (Bernhard Nocht Institute for Tropical Medicine (BNITM)
    World Health Organization (WHO))

  • Cheikh Loucoubar

    (Institut Pasteur de Dakar (IPD))

  • Ibrahima Camara

    (Université de Conakry)

  • Karifa Kourouma

    (Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG)
    Bernhard Nocht Institute for Tropical Medicine (BNITM))

  • Giuditta Annibaldis

    (Bernhard Nocht Institute for Tropical Medicine (BNITM)
    World Health Organization (WHO))

  • Assaïtou Bah

    (Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG))

  • Anke Thielebein

    (Bernhard Nocht Institute for Tropical Medicine (BNITM)
    Partner Site Hamburg–Lübeck–Borstel–Riems)

  • Meike Pahlmann

    (Bernhard Nocht Institute for Tropical Medicine (BNITM)
    Partner Site Hamburg–Lübeck–Borstel–Riems)

  • Steven T. Pullan

    (UK Health Security Agency, National Infection Service, Porton Down
    University of Oxford)

  • Miles W. Carroll

    (UK Health Security Agency, National Infection Service, Porton Down
    University of Oxford)

  • Joshua Quick

    (University of Birmingham)

  • Pierre Formenty

    (World Health Organization (WHO))

  • Anais Legand

    (World Health Organization (WHO))

  • Karla Pietro

    (PraesensBio)

  • Michael R. Wiley

    (PraesensBio
    University of Nebraska Medical Center)

  • Noel Tordo

    (Institut Pasteur de Guinée)

  • Christophe Peyrefitte

    (Institut Pasteur de Dakar (IPD))

  • John T. McCrone

    (University of Edinburgh)

  • Andrew Rambaut

    (University of Edinburgh)

  • Youssouf Sidibé

    (Hôpital Régional de Nzérékoré)

  • Mamadou D. Barry

    (Hôpital Régional de Nzérékoré)

  • Madeleine Kourouma

    (Hôpital Régional de Nzérékoré)

  • Cé D. Saouromou

    (Hôpital Régional de Nzérékoré)

  • Mamadou Condé

    (Hôpital Régional de Nzérékoré)

  • Moussa Baldé

    (Hôpital National Donka, Service des Maladies Infectieuses et Tropicales)

  • Moriba Povogui

    (Université de Conakry)

  • Sakoba Keita

    (Agence Nationale de Sécurité Sanitaire)

  • Mandiou Diakite

    (Ministère de la Santé
    Université Gamal Abdel Nasser de Conakry)

  • Mamadou S. Bah

    (Ministère de la Santé)

  • Amadou Sidibe

    (Ecole Nationale Supérieure de Lyon)

  • Dembo Diakite

    (Hôpital National Donka, Service des Maladies Infectieuses et Tropicales)

  • Fodé B. Sako

    (Hôpital National Donka, Service des Maladies Infectieuses et Tropicales)

  • Fodé A. Traore

    (Hôpital National Donka, Service des Maladies Infectieuses et Tropicales)

  • Georges A. Ki-Zerbo

    (World Health Organization (WHO))

  • Philippe Lemey

    (Immunology and Transplantation, Rega Institute, KU Leuven)

  • Stephan Günther

    (Bernhard Nocht Institute for Tropical Medicine (BNITM)
    Partner Site Hamburg–Lübeck–Borstel–Riems
    World Health Organization (WHO))

  • Liana E. Kafetzopoulou

    (Bernhard Nocht Institute for Tropical Medicine (BNITM)
    Partner Site Hamburg–Lübeck–Borstel–Riems
    Immunology and Transplantation, Rega Institute, KU Leuven)

  • Amadou A. Sall

    (Institut Pasteur de Dakar (IPD))

  • Eric Delaporte

    (TransVIHMI, Montpellier University/IRD/INSERM
    University Hospital Montpellier)

  • Sophie Duraffour

    (Bernhard Nocht Institute for Tropical Medicine (BNITM)
    Partner Site Hamburg–Lübeck–Borstel–Riems
    World Health Organization (WHO))

  • Ousmane Faye

    (Institut Pasteur de Dakar (IPD))

  • Fabian H. Leendertz

    (Robert Koch Institute (RKI))

  • Martine Peeters

    (TransVIHMI, Montpellier University/IRD/INSERM)

  • Abdoulaye Toure

    (Université de Conakry
    Institut National de Santé Publique de Guinée (INSP))

  • N’. Faly Magassouba

    (Laboratoire du Projet des Fièvres Hémorragiques de Guinée (PFHG))

Abstract

Seven years after the declaration of the first epidemic of Ebola virus disease in Guinea, the country faced a new outbreak—between 14 February and 19 June 2021—near the epicentre of the previous epidemic1,2. Here we use next-generation sequencing to generate complete or near-complete genomes of Zaire ebolavirus from samples obtained from 12 different patients. These genomes form a well-supported phylogenetic cluster with genomes from the previous outbreak, which indicates that the new outbreak was not the result of a new spillover event from an animal reservoir. The 2021 lineage shows considerably lower divergence than would be expected during sustained human-to-human transmission, which suggests a persistent infection with reduced replication or a period of latency. The resurgence of Zaire ebolavirus from humans five years after the end of the previous outbreak of Ebola virus disease reinforces the need for long-term medical and social care for patients who survive the disease, to reduce the risk of re-emergence and to prevent further stigmatization.

Suggested Citation

  • Alpha Kabinet Keita & Fara R. Koundouno & Martin Faye & Ariane Düx & Julia Hinzmann & Haby Diallo & Ahidjo Ayouba & Frederic Le Marcis & Barré Soropogui & Kékoura Ifono & Moussa M. Diagne & Mamadou S., 2021. "Resurgence of Ebola virus in 2021 in Guinea suggests a new paradigm for outbreaks," Nature, Nature, vol. 597(7877), pages 539-543, September.
    • Handle: RePEc:nat:nature:v:597:y:2021:i:7877:d:10.1038_s41586-021-03901-9
    DOI: 10.1038/s41586-021-03901-9
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    Cited by:

    1. Joseph Akoi Boré & Joseph W. S. Timothy & Tom Tipton & Ifono Kekoura & Yper Hall & Grace Hood & Stephanie Longet & Kimberly Fornace & Millimono S. Lucien & Sarah Katarina Fehling & Beatrice K. Koivogu, 2024. "Serological evidence of zoonotic filovirus exposure among bushmeat hunters in Guinea," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
    2. S. A. Riesle-Sbarbaro & G. Wibbelt & A. Düx & V. Kouakou & M. Bokelmann & K. Hansen-Kant & N. Kirchoff & M. Laue & N. Kromarek & A. Lander & U. Vogel & A. Wahlbrink & D. M. Wozniak & D. P. Scott & J. , 2024. "Selective replication and vertical transmission of Ebola virus in experimentally infected Angolan free-tailed bats," Nature Communications, Nature, vol. 15(1), pages 1-15, December.
    3. Mostafa Bentahir & Mamadou Diouldé Barry & Kekoura Koulemou & Jean-Luc Gala, 2022. "Providing On-Site Laboratory and Biosafety Just-In-Time Training Inside a Box-Based Laboratory during the West Africa Ebola Outbreak: Supporting Better Preparedness for Future Health Emergencies," IJERPH, MDPI, vol. 19(18), pages 1-13, September.

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