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Planar cell polarity proteins mediate ketamine-induced restoration of glutamatergic synapses in prefrontal cortical neurons in a mouse model for chronic stress

Author

Listed:
  • Andiara E. Freitas

    (San Diego)

  • Bo Feng

    (San Diego)

  • Timothy Woo

    (San Diego)

  • Shae Galli

    (San Diego)

  • Clayton Baker

    (San Diego)

  • Yue Ban

    (San Diego)

  • Jonathan Truong

    (San Diego)

  • Anna Beyeler

    (Rue Leo Saignat)

  • Yimin Zou

    (San Diego)

Abstract

Single administration of low-dose ketamine has both acute and sustained anti-depressant effects. Sustained effect is associated with restoration of glutamatergic synapses in medial prefrontal cortic (mFPC) neurons. Ketamine induced profound changes in a number of molecular pathways in a mouse model for chronic stress. Cell-cell communication analyses predicted that planar-cell-polarity (PCP) signaling was decreased after chronic administration of corticosterone but increased following ketamine administration in most of the excitatory neurons. Similar decrease of PCP signaling in excitatory neurons was predicted in dorsolateral prefrontal cortical (dl-PFC) neurons of patients with major depressive disorder (MDD). We showed that the basolateral amygdala (BLA)-projecting infralimbic prefrontal cortex (IL PFC) neurons regulate immobility time in the tail suspension test and food consumption. Conditionally knocking out Celsr2 and Celsr3 or Prickle2 in the BLA-projecting IL PFC neurons abolished ketamine-induced synapse restoration and behavioral remission. Therefore, PCP proteins in IL PFC-BLA neurons mediate synapse restoration induced by of low-dose ketamine.

Suggested Citation

  • Andiara E. Freitas & Bo Feng & Timothy Woo & Shae Galli & Clayton Baker & Yue Ban & Jonathan Truong & Anna Beyeler & Yimin Zou, 2024. "Planar cell polarity proteins mediate ketamine-induced restoration of glutamatergic synapses in prefrontal cortical neurons in a mouse model for chronic stress," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-48257-6
    DOI: 10.1038/s41467-024-48257-6
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