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Crown ether decorated silicon photonics for safeguarding against lead poisoning

Author

Listed:
  • Luigi Ranno

    (Massachusetts Institute of Technology)

  • Yong Zen Tan

    (Fingate Technologies Pte Ltd)

  • Chi Siang Ong

    (Fingate Technologies Pte Ltd)

  • Xin Guo

    (Nanyang Technological University)

  • Khong Nee Koo

    (Kampung Kerinchi)

  • Xiang Li

    (Nanyang Technological University)

  • Wanjun Wang

    (Nanyang Technological University)

  • Samuel Serna

    (Massachusetts Institute of Technology)

  • Chongyang Liu

    (Nanyang Technological University)

  • Rusli

    (Nanyang Technological University)

  • Callum G. Littlejohns

    (University of Southampton)

  • Graham T. Reed

    (University of Southampton)

  • Juejun Hu

    (Massachusetts Institute of Technology)

  • Hong Wang

    (Nanyang Technological University)

  • Jia Xu Brian Sia

    (Massachusetts Institute of Technology
    Nanyang Technological University)

Abstract

Lead (Pb2+) toxification is a concerning, unaddressed global public health crisis that leads to 1 million deaths annually. Yet, public policies to address this issue have fallen short. This work harnesses the unique abilities of crown ethers, which selectively bind to specific ions. This study demonstrates the synergistic integration of highly-scalable silicon photonics, with crown ether amine conjugation via Fischer esterification in an environmentally-friendly fashion. This realizes an integrated photonic platform that enables the in-operando, highly-selective and quantitative detection of various ions. The development dispels the existing notion that Fischer esterification is restricted to organic compounds, facilitating the subsequent amine conjugation for various crown ethers. The presented platform is specifically engineered for selective Pb2+ detection, demonstrating a large dynamic detection range, and applicability to field samples. The compatibility of this platform with cost-effective manufacturing indicates the potential for pervasive implementation of the integrated photonic sensor technology to safeguard against societal Pb2+ poisoning.

Suggested Citation

  • Luigi Ranno & Yong Zen Tan & Chi Siang Ong & Xin Guo & Khong Nee Koo & Xiang Li & Wanjun Wang & Samuel Serna & Chongyang Liu & Rusli & Callum G. Littlejohns & Graham T. Reed & Juejun Hu & Hong Wang & , 2024. "Crown ether decorated silicon photonics for safeguarding against lead poisoning," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47938-6
    DOI: 10.1038/s41467-024-47938-6
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    References listed on IDEAS

    as
    1. Derek M. Kita & Brando Miranda & David Favela & David Bono & Jérôme Michon & Hongtao Lin & Tian Gu & Juejun Hu, 2018. "High-performance and scalable on-chip digital Fourier transform spectroscopy," Nature Communications, Nature, vol. 9(1), pages 1-7, December.
    2. Junjie Guo & Jaekwang Lee & Cristian I. Contescu & Nidia C. Gallego & Sokrates T. Pantelides & Stephen J. Pennycook & Bruce A. Moyer & Matthew F. Chisholm, 2014. "Crown ethers in graphene," Nature Communications, Nature, vol. 5(1), pages 1-6, December.
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