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An ancestral SARS-CoV-2 vaccine induces anti-Omicron variants antibodies by hypermutation

Author

Listed:
  • Seoryeong Park

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Jaewon Choi

    (Seoul National University
    Seoul National University)

  • Yonghee Lee

    (Seoul National University)

  • Jinsung Noh

    (Seoul National University
    Seoul National University)

  • Namphil Kim

    (Seoul National University)

  • JinAh Lee

    (Institut Pasteur Korea)

  • Geummi Cho

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Sujeong Kim

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Duck Kyun Yoo

    (Seoul National University College of Medicine
    Seoul National University College of Medicine)

  • Chang Kyung Kang

    (Seoul National University College of Medicine)

  • Pyoeng Gyun Choe

    (Seoul National University College of Medicine)

  • Nam Joong Kim

    (Seoul National University College of Medicine)

  • Wan Beom Park

    (Seoul National University College of Medicine)

  • Seungtaek Kim

    (Institut Pasteur Korea)

  • Myoung-don Oh

    (Seoul National University College of Medicine)

  • Sunghoon Kwon

    (Seoul National University
    Seoul National University
    Seoul National University)

  • Junho Chung

    (Seoul National University College of Medicine
    Seoul National University College of Medicine
    Seoul National University College of Medicine)

Abstract

The immune escape of Omicron variants significantly subsides by the third dose of an mRNA vaccine. However, it is unclear how Omicron variant-neutralizing antibodies develop under repeated vaccination. We analyze blood samples from 41 BNT162b2 vaccinees following the course of three injections and analyze their B-cell receptor (BCR) repertoires at six time points in total. The concomitant reactivity to both ancestral and Omicron receptor-binding domain (RBD) is achieved by a limited number of BCR clonotypes depending on the accumulation of somatic hypermutation (SHM) after the third dose. Our findings suggest that SHM accumulation in the BCR space to broaden its specificity for unseen antigens is a counterprotective mechanism against virus variant immune escape.

Suggested Citation

  • Seoryeong Park & Jaewon Choi & Yonghee Lee & Jinsung Noh & Namphil Kim & JinAh Lee & Geummi Cho & Sujeong Kim & Duck Kyun Yoo & Chang Kyung Kang & Pyoeng Gyun Choe & Nam Joong Kim & Wan Beom Park & Se, 2024. "An ancestral SARS-CoV-2 vaccine induces anti-Omicron variants antibodies by hypermutation," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47743-1
    DOI: 10.1038/s41467-024-47743-1
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