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Paternal dietary macronutrient balance and energy intake drive metabolic and behavioral differences among offspring

Author

Listed:
  • Angela Jane Crean

    (The University of Sydney)

  • Alistair McNair Senior

    (The University of Sydney)

  • Therese Freire

    (The University of Sydney)

  • Thomas Daniel Clark

    (The University of Sydney)

  • Flora Mackay

    (The University of Sydney)

  • Gracie Austin

    (The University of Sydney)

  • Tamara Jayne Pulpitel

    (The University of Sydney)

  • Marcelo Aguiar Nobrega

    (University of Chicago)

  • Romain Barrès

    (University of Copenhagen
    Université Côte d’Azur & Centre National pour la Recherche Scientifique (CNRS))

  • Stephen James Simpson

    (The University of Sydney)

Abstract

Paternal diet can influence the phenotype of the next generation, yet, the dietary components inducing specific responses in the offspring are not identified. Here, we use the Nutritional Geometry Framework to determine the effects of pre-conception paternal dietary macronutrient balance on offspring metabolic and behavioral traits in mice. Ten isocaloric diets varying in the relative proportion of protein, fats, and carbohydrates are fed to male mice prior to mating. Dams and offspring are fed standard chow and never exposed to treatment diets. Body fat in female offspring is positively associated with the paternal consumption of fat, while in male offspring, an anxiety-like phenotype is associated to paternal diets low in protein and high in carbohydrates. Our study uncovers that the nature and the magnitude of paternal effects are driven by interactions between macronutrient balance and energy intake and are not solely the result of over- or undernutrition.

Suggested Citation

  • Angela Jane Crean & Alistair McNair Senior & Therese Freire & Thomas Daniel Clark & Flora Mackay & Gracie Austin & Tamara Jayne Pulpitel & Marcelo Aguiar Nobrega & Romain Barrès & Stephen James Simpso, 2024. "Paternal dietary macronutrient balance and energy intake drive metabolic and behavioral differences among offspring," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-46782-y
    DOI: 10.1038/s41467-024-46782-y
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    References listed on IDEAS

    as
    1. Sheau-Fang Ng & Ruby C. Y. Lin & D. Ross Laybutt & Romain Barres & Julie A. Owens & Margaret J. Morris, 2010. "Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring," Nature, Nature, vol. 467(7318), pages 963-966, October.
    2. A. J. Crean & S. Afrin & H. Niranjan & T. J. Pulpitel & G. Ahmad & A. M. Senior & T. Freire & F. Mackay & M. A. Nobrega & R. Barrès & S. J. Simpson & T. Pini, 2023. "Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
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