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Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity

Author

Listed:
  • A. J. Crean

    (The University of Sydney)

  • S. Afrin

    (The University of Sydney)

  • H. Niranjan

    (The University of Sydney)

  • T. J. Pulpitel

    (The University of Sydney)

  • G. Ahmad

    (The University of Sydney
    Royal Women’s Hospital)

  • A. M. Senior

    (The University of Sydney)

  • T. Freire

    (The University of Sydney)

  • F. Mackay

    (The University of Sydney)

  • M. A. Nobrega

    (University of Chicago)

  • R. Barrès

    (University of Copenhagen
    Universite´ Coˆ te d’Azur & Centre National pour la Recherche Scientifique (CNRS))

  • S. J. Simpson

    (The University of Sydney)

  • T. Pini

    (The University of Sydney
    The University of Queensland)

Abstract

Dietary factors influence male reproductive function in both experimental and epidemiological studies. However, there are currently no specific dietary guidelines for male preconception health. Here, we use the Nutritional Geometry framework to examine the effects of dietary macronutrient balance on reproductive traits in C57BL/6 J male mice. Dietary effects are observed in a range of morphological, testicular and spermatozoa traits, although the relative influence of protein, fat, carbohydrate, and their interactions differ depending on the trait being examined. Interestingly, dietary fat has a positive influence on sperm motility and antioxidant capacity, differing to typical high fat diet studies where calorie content is not controlled for. Moreover, body adiposity is not significantly correlated with any of the reproductive traits measured in this study. These results demonstrate the importance of macronutrient balance and calorie intake on reproductive function and support the need to develop specific, targeted, preconception dietary guidelines for males.

Suggested Citation

  • A. J. Crean & S. Afrin & H. Niranjan & T. J. Pulpitel & G. Ahmad & A. M. Senior & T. Freire & F. Mackay & M. A. Nobrega & R. Barrès & S. J. Simpson & T. Pini, 2023. "Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38314-x
    DOI: 10.1038/s41467-023-38314-x
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    Cited by:

    1. Angela Jane Crean & Alistair McNair Senior & Therese Freire & Thomas Daniel Clark & Flora Mackay & Gracie Austin & Tamara Jayne Pulpitel & Marcelo Aguiar Nobrega & Romain Barrès & Stephen James Simpso, 2024. "Paternal dietary macronutrient balance and energy intake drive metabolic and behavioral differences among offspring," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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