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Parents’ smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation study

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Listed:
  • Gerd Toril Mørkve Knudsen
  • Shyamali Dharmage
  • Christer Janson
  • Michael J Abramson
  • Bryndís Benediktsdóttir
  • Andrei Malinovschi
  • Svein Magne Skulstad
  • Randi Jacobsen Bertelsen
  • Francisco Gomez Real
  • Vivi Schlünssen
  • Nils Oskar Jõgi
  • José Luis Sánchez-Ramos
  • Mathias Holm
  • Judith Garcia-Aymerich
  • Bertil Forsberg
  • Cecilie Svanes
  • Ane Johannessen

Abstract

Emerging evidence suggests that parents’ preconception exposures may influence offspring health. We aimed to investigate maternal and paternal smoking onset in specific time windows in relation to offspring body mass index (BMI) and fat mass index (FMI). We investigated fathers (n = 2111) and mothers (n = 2569) aged 39–65 years, of the population based RHINE and ECRHS studies, and their offspring aged 18–49 years (n = 6487, mean age 29.6 years) who participated in the RHINESSA study. BMI was calculated from self-reported height and weight, and FMI was estimated from bioelectrical impedance measures in a subsample. Associations with parental smoking were analysed with generalized linear regression adjusting for parental education and clustering by study centre and family. Interactions between offspring sex were analysed, as was mediation by parental pack years, parental BMI, offspring smoking and offspring birthweight. Fathers’ smoking onset before conception of the offspring (onset ≥15 years) was associated with higher BMI in the offspring when adult (β 0.551, 95%CI: 0.174–0.929, p = 0.004). Mothers’ preconception and postnatal smoking onset was associated with higher offspring BMI (onset

Suggested Citation

  • Gerd Toril Mørkve Knudsen & Shyamali Dharmage & Christer Janson & Michael J Abramson & Bryndís Benediktsdóttir & Andrei Malinovschi & Svein Magne Skulstad & Randi Jacobsen Bertelsen & Francisco Gomez , 2020. "Parents’ smoking onset before conception as related to body mass index and fat mass in adult offspring: Findings from the RHINESSA generation study," PLOS ONE, Public Library of Science, vol. 15(7), pages 1-20, July.
    • Handle: RePEc:plo:pone00:0235632
    DOI: 10.1371/journal.pone.0235632
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    References listed on IDEAS

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    1. Steen, Johan & Loeys, Tom & Moerkerke, Beatrijs & Vansteelandt, Stijn, 2017. "medflex: An R Package for Flexible Mediation Analysis using Natural Effect Models," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 76(i11).
    2. Sheau-Fang Ng & Ruby C. Y. Lin & D. Ross Laybutt & Romain Barres & Julie A. Owens & Margaret J. Morris, 2010. "Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring," Nature, Nature, vol. 467(7318), pages 963-966, October.
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