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Protective effects of Pt-N-C single-atom nanozymes against myocardial ischemia-reperfusion injury

Author

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  • Tianbao Ye

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Jiao Tong University)

  • Cheng Chen

    (Tongji University)

  • Di Wang

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
    Shanghai Jiao Tong University School of Medicine)

  • Chengjie Huang

    (Shanghai Jiao Tong University)

  • Zhiwen Yan

    (Youth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine)

  • Yu Chen

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Xian Jin

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Xiuyuan Wang

    (Fudan University)

  • Xianting Ding

    (Shanghai Jiao Tong University)

  • Chengxing Shen

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

Abstract

Effective therapeutic strategies for myocardial ischemia/reperfusion (I/R) injury remain elusive. Targeting reactive oxygen species (ROS) provides a practical approach to mitigate myocardial damage following reperfusion. In this study, we synthesize an antioxidant nanozyme, equipped with a single-Platinum (Pt)-atom (PtsaN-C), for protecting against I/R injury. PtsaN-C exhibits multiple enzyme-mimicking activities for ROS scavenging with high efficiency and stability. Mechanistic studies demonstrate that the excellent ROS-elimination performance of the single Pt atom center precedes that of the Pt cluster center, owing to its better synergistic effect and metallic electronic property. Systematic in vitro and in vivo studies confirm that PtsaN-C efficiently counteracts ROS, restores cellular homeostasis and prevents apoptotic progression after I/R injury. PtsaN-C also demonstrates good biocompatibility, making it a promising candidate for clinical applications. Our study expands the scope of single-atom nanozyme in combating ROS-induced damage and offers a promising therapeutic avenue for the treatment of I/R injury.

Suggested Citation

  • Tianbao Ye & Cheng Chen & Di Wang & Chengjie Huang & Zhiwen Yan & Yu Chen & Xian Jin & Xiuyuan Wang & Xianting Ding & Chengxing Shen, 2024. "Protective effects of Pt-N-C single-atom nanozymes against myocardial ischemia-reperfusion injury," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45927-3
    DOI: 10.1038/s41467-024-45927-3
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    References listed on IDEAS

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    1. Taejung Lim & Gwan Yeong Jung & Jae Hyung Kim & Sung O Park & Jaehyun Park & Yong-Tae Kim & Seok Ju Kang & Hu Young Jeong & Sang Kyu Kwak & Sang Hoon Joo, 2020. "Atomically dispersed Pt–N4 sites as efficient and selective electrocatalysts for the chlorine evolution reaction," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
    2. Jing Mu & Chunxiao Li & Yu Shi & Guoyong Liu & Jianhua Zou & Dong-Yang Zhang & Chao Jiang & Xiuli Wang & Liangcan He & Peng Huang & Yuxin Yin & Xiaoyuan Chen, 2022. "Protective effect of platinum nano-antioxidant and nitric oxide against hepatic ischemia-reperfusion injury," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Lijun Wang & Jiaqi Wang & Pujiao Yu & Jingyi Feng & Gui-e Xu & Xuan Zhao & Tianhui Wang & H. Immo Lehmann & Guoping Li & Joost P. G. Sluijter & Junjie Xiao, 2022. "METTL14 is required for exercise-induced cardiac hypertrophy and protects against myocardial ischemia-reperfusion injury," Nature Communications, Nature, vol. 13(1), pages 1-21, December.
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