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Numerosity estimation of virtual humans as a digital-robotic marker for hallucinations in Parkinson’s disease

Author

Listed:
  • Louis Albert

    (Neuro-X Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (EPFL))

  • Jevita Potheegadoo

    (Neuro-X Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (EPFL))

  • Bruno Herbelin

    (Neuro-X Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (EPFL))

  • Fosco Bernasconi

    (Neuro-X Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (EPFL))

  • Olaf Blanke

    (Neuro-X Institute, Faculty of Life Sciences, Swiss Federal Institute of Technology (EPFL)
    University of Geneva)

Abstract

Hallucinations are frequent non-motor symptoms in Parkinson’s disease (PD) associated with dementia and higher mortality. Despite their high clinical relevance, current assessments of hallucinations are based on verbal self-reports and interviews that are limited by important biases. Here, we used virtual reality (VR), robotics, and digital online technology to quantify presence hallucination (vivid sensations that another person is nearby when no one is actually present and can neither be seen nor heard) in laboratory and home-based settings. We establish that elevated numerosity estimation of virtual human agents in VR is a digital marker for experimentally induced presence hallucinations in healthy participants, as confirmed across several control conditions and analyses. We translated the digital marker (numerosity estimation) to an online procedure that 170 PD patients carried out remotely at their homes, revealing that PD patients with disease-related presence hallucinations (but not control PD patients) showed higher numerosity estimation. Numerosity estimation enables quantitative monitoring of hallucinations, is an easy-to-use unobtrusive online method, reaching people far away from medical centers, translating neuroscientific findings using robotics and VR, to patients’ homes without specific equipment or trained staff.

Suggested Citation

  • Louis Albert & Jevita Potheegadoo & Bruno Herbelin & Fosco Bernasconi & Olaf Blanke, 2024. "Numerosity estimation of virtual humans as a digital-robotic marker for hallucinations in Parkinson’s disease," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45912-w
    DOI: 10.1038/s41467-024-45912-w
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    References listed on IDEAS

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    1. Bates, Douglas & Mächler, Martin & Bolker, Ben & Walker, Steve, 2015. "Fitting Linear Mixed-Effects Models Using lme4," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 67(i01).
    2. Tingley, Dustin & Yamamoto, Teppei & Hirose, Kentaro & Keele, Luke & Imai, Kosuke, 2014. "mediation: R Package for Causal Mediation Analysis," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 59(i05).
    3. Shahar Arzy & Margitta Seeck & Stephanie Ortigue & Laurent Spinelli & Olaf Blanke, 2006. "Induction of an illusory shadow person," Nature, Nature, vol. 443(7109), pages 287-287, September.
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