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Host association and intracellularity evolved multiple times independently in the Rickettsiales

Author

Listed:
  • Michele Castelli

    (University of Pavia)

  • Tiago Nardi

    (University of Pavia)

  • Leandro Gammuto

    (University of Pisa)

  • Greta Bellinzona

    (University of Pavia)

  • Elena Sabaneyeva

    (Saint Petersburg State University)

  • Alexey Potekhin

    (Saint Petersburg State University
    University of Innsbruck)

  • Valentina Serra

    (University of Pisa)

  • Giulio Petroni

    (University of Pisa)

  • Davide Sassera

    (University of Pavia
    IRCCS Policlinico San Matteo)

Abstract

The order Rickettsiales (Alphaproteobacteria) encompasses multiple diverse lineages of host-associated bacteria, including pathogens, reproductive manipulators, and mutualists. Here, in order to understand how intracellularity and host association originated in this order, and whether they are ancestral or convergently evolved characteristics, we built a large and phylogenetically-balanced dataset that includes de novo sequenced genomes and a selection of published genomic and metagenomic assemblies. We perform detailed functional reconstructions that clearly indicates “late” and parallel evolution of obligate host-association in different Rickettsiales lineages. According to the depicted scenario, multiple independent horizontal acquisitions of transporters led to the progressive loss of biosynthesis of nucleotides, amino acids and other metabolites, producing distinct conditions of host-dependence. Each clade experienced a different pattern of evolution of the ancestral arsenal of interaction apparatuses, including development of specialised effectors involved in the lineage-specific mechanisms of host cell adhesion and/or invasion.

Suggested Citation

  • Michele Castelli & Tiago Nardi & Leandro Gammuto & Greta Bellinzona & Elena Sabaneyeva & Alexey Potekhin & Valentina Serra & Giulio Petroni & Davide Sassera, 2024. "Host association and intracellularity evolved multiple times independently in the Rickettsiales," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-45351-7
    DOI: 10.1038/s41467-024-45351-7
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    References listed on IDEAS

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    1. Hiroyuki Imachi & Masaru K. Nobu & Nozomi Nakahara & Yuki Morono & Miyuki Ogawara & Yoshihiro Takaki & Yoshinori Takano & Katsuyuki Uematsu & Tetsuro Ikuta & Motoo Ito & Yohei Matsui & Masayuki Miyaza, 2020. "Isolation of an archaeon at the prokaryote–eukaryote interface," Nature, Nature, vol. 577(7791), pages 519-525, January.
    2. Sishuo Wang & Haiwei Luo, 2021. "Dating Alphaproteobacteria evolution with eukaryotic fossils," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    3. Gina M. Borgo & Thomas P. Burke & Cuong J. Tran & Nicholas T. N. Lo & Patrik Engström & Matthew D. Welch, 2022. "A patatin-like phospholipase mediates Rickettsia parkeri escape from host membranes," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
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