IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-44822-1.html
   My bibliography  Save this article

Micrometer-thick and porous nanocomposite coating for electrochemical sensors with exceptional antifouling and electroconducting properties

Author

Listed:
  • Jeong-Chan Lee

    (Harvard University
    Korea Advanced Institute of Science and Technology (KAIST))

  • Su Yeong Kim

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Jayeon Song

    (Korea Research Institute of Bioscience and Biotechnology (KRIBB)
    Massachusetts General Hospital Research Institute
    Harvard Medical School)

  • Hyowon Jang

    (Korea Research Institute of Bioscience and Biotechnology (KRIBB))

  • Min Kim

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Hanul Kim

    (Department of Chemical and Biomolecular Engineering, KAIST)

  • Siyoung Q. Choi

    (Department of Chemical and Biomolecular Engineering, KAIST)

  • Sunjoo Kim

    (Gyeongsang National University College of Medicine)

  • Pawan Jolly

    (Harvard University)

  • Taejoon Kang

    (Korea Research Institute of Bioscience and Biotechnology (KRIBB)
    School of Pharmacy, Sungkyunkwan University (SKKU))

  • Steve Park

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Donald E. Ingber

    (Harvard University
    Boston Children’s Hospital and Harvard Medical School
    Harvard University)

Abstract

Development of coating technologies for electrochemical sensors that consistently exhibit antifouling activities in diverse and complex biological environments over extended time is vital for effective medical devices and diagnostics. Here, we describe a micrometer-thick, porous nanocomposite coating with both antifouling and electroconducting properties that enhances the sensitivity of electrochemical sensors. Nozzle printing of oil-in-water emulsion is used to create a 1 micrometer thick coating composed of cross-linked albumin with interconnected pores and gold nanowires. The layer resists biofouling and maintains rapid electron transfer kinetics for over one month when exposed directly to complex biological fluids, including serum and nasopharyngeal secretions. Compared to a thinner (nanometer thick) antifouling coating made with drop casting or a spin coating of the same thickness, the thick porous nanocomposite sensor exhibits sensitivities that are enhanced by 3.75- to 17-fold when three different target biomolecules are tested. As a result, emulsion-coated, multiplexed electrochemical sensors can carry out simultaneous detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid, antigen, and host antibody in clinical specimens with high sensitivity and specificity. This thick porous emulsion coating technology holds promise in addressing hurdles currently restricting the application of electrochemical sensors for point-of-care diagnostics, implantable devices, and other healthcare monitoring systems.

Suggested Citation

  • Jeong-Chan Lee & Su Yeong Kim & Jayeon Song & Hyowon Jang & Min Kim & Hanul Kim & Siyoung Q. Choi & Sunjoo Kim & Pawan Jolly & Taejoon Kang & Steve Park & Donald E. Ingber, 2024. "Micrometer-thick and porous nanocomposite coating for electrochemical sensors with exceptional antifouling and electroconducting properties," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44822-1
    DOI: 10.1038/s41467-024-44822-1
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-44822-1
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-024-44822-1?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Ramesh Yelagandula & Aleksandr Bykov & Alexander Vogt & Robert Heinen & Ezgi Özkan & Marcus Martin Strobl & Juliane Christina Baar & Kristina Uzunova & Bence Hajdusits & Darja Kordic & Erna Suljic & A, 2021. "Multiplexed detection of SARS-CoV-2 and other respiratory infections in high throughput by SARSeq," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
    2. Joshua T. Atkinson & Lin Su & Xu Zhang & George N. Bennett & Jonathan J. Silberg & Caroline M. Ajo-Franklin, 2022. "Real-time bioelectronic sensing of environmental contaminants," Nature, Nature, vol. 611(7936), pages 548-553, November.
    3. Ingrid F. Guha & Sushant Anand & Kripa K. Varanasi, 2017. "Creating nanoscale emulsions using condensation," Nature Communications, Nature, vol. 8(1), pages 1-7, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Sihan Tang & Jiang Gong & Yunsong Shi & Shifeng Wen & Qiang Zhao, 2022. "Spontaneous water-on-water spreading of polyelectrolyte membranes inspired by skin formation," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    2. Sally Wang & Chen-Yu Chen & John R. Rzasa & Chen-Yu Tsao & Jinyang Li & Eric VanArsdale & Eunkyoung Kim & Fauziah Rahma Zakaria & Gregory F. Payne & William E. Bentley, 2023. "Redox-enabled electronic interrogation and feedback control of hierarchical and networked biological systems," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Ren Ren & Shenglin Cai & Xiaona Fang & Xiaoyi Wang & Zheng Zhang & Micol Damiani & Charlotte Hudlerova & Annachiara Rosa & Joshua Hope & Nicola J. Cook & Peter Gorelkin & Alexander Erofeev & Pavel Nov, 2023. "Multiplexed detection of viral antigen and RNA using nanopore sensing and encoded molecular probes," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    4. Yang Gao & Yuchen Zhou & Xudong Ji & Austin J. Graham & Christopher M. Dundas & Ismar E. Miniel Mahfoud & Bailey M. Tibbett & Benjamin Tan & Gina Partipilo & Ananth Dodabalapur & Jonathan Rivnay & Ben, 2024. "A hybrid transistor with transcriptionally controlled computation and plasticity," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    5. Dalton R. George & Mark Danciu & Peter W. Davenport & Matthew R. Lakin & James Chappell & Emma K. Frow, 2024. "A bumpy road ahead for genetic biocontainment," Nature Communications, Nature, vol. 15(1), pages 1-5, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44822-1. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.