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Micrometer-thick and porous nanocomposite coating for electrochemical sensors with exceptional antifouling and electroconducting properties

Author

Listed:
  • Jeong-Chan Lee

    (Harvard University
    Korea Advanced Institute of Science and Technology (KAIST))

  • Su Yeong Kim

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Jayeon Song

    (Korea Research Institute of Bioscience and Biotechnology (KRIBB)
    Massachusetts General Hospital Research Institute
    Harvard Medical School)

  • Hyowon Jang

    (Korea Research Institute of Bioscience and Biotechnology (KRIBB))

  • Min Kim

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Hanul Kim

    (Department of Chemical and Biomolecular Engineering, KAIST)

  • Siyoung Q. Choi

    (Department of Chemical and Biomolecular Engineering, KAIST)

  • Sunjoo Kim

    (Gyeongsang National University College of Medicine)

  • Pawan Jolly

    (Harvard University)

  • Taejoon Kang

    (Korea Research Institute of Bioscience and Biotechnology (KRIBB)
    School of Pharmacy, Sungkyunkwan University (SKKU))

  • Steve Park

    (Korea Advanced Institute of Science and Technology (KAIST))

  • Donald E. Ingber

    (Harvard University
    Boston Children’s Hospital and Harvard Medical School
    Harvard University)

Abstract

Development of coating technologies for electrochemical sensors that consistently exhibit antifouling activities in diverse and complex biological environments over extended time is vital for effective medical devices and diagnostics. Here, we describe a micrometer-thick, porous nanocomposite coating with both antifouling and electroconducting properties that enhances the sensitivity of electrochemical sensors. Nozzle printing of oil-in-water emulsion is used to create a 1 micrometer thick coating composed of cross-linked albumin with interconnected pores and gold nanowires. The layer resists biofouling and maintains rapid electron transfer kinetics for over one month when exposed directly to complex biological fluids, including serum and nasopharyngeal secretions. Compared to a thinner (nanometer thick) antifouling coating made with drop casting or a spin coating of the same thickness, the thick porous nanocomposite sensor exhibits sensitivities that are enhanced by 3.75- to 17-fold when three different target biomolecules are tested. As a result, emulsion-coated, multiplexed electrochemical sensors can carry out simultaneous detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid, antigen, and host antibody in clinical specimens with high sensitivity and specificity. This thick porous emulsion coating technology holds promise in addressing hurdles currently restricting the application of electrochemical sensors for point-of-care diagnostics, implantable devices, and other healthcare monitoring systems.

Suggested Citation

  • Jeong-Chan Lee & Su Yeong Kim & Jayeon Song & Hyowon Jang & Min Kim & Hanul Kim & Siyoung Q. Choi & Sunjoo Kim & Pawan Jolly & Taejoon Kang & Steve Park & Donald E. Ingber, 2024. "Micrometer-thick and porous nanocomposite coating for electrochemical sensors with exceptional antifouling and electroconducting properties," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-44822-1
    DOI: 10.1038/s41467-024-44822-1
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    References listed on IDEAS

    as
    1. Joshua T. Atkinson & Lin Su & Xu Zhang & George N. Bennett & Jonathan J. Silberg & Caroline M. Ajo-Franklin, 2022. "Real-time bioelectronic sensing of environmental contaminants," Nature, Nature, vol. 611(7936), pages 548-553, November.
    2. Ingrid F. Guha & Sushant Anand & Kripa K. Varanasi, 2017. "Creating nanoscale emulsions using condensation," Nature Communications, Nature, vol. 8(1), pages 1-7, December.
    3. Ramesh Yelagandula & Aleksandr Bykov & Alexander Vogt & Robert Heinen & Ezgi Özkan & Marcus Martin Strobl & Juliane Christina Baar & Kristina Uzunova & Bence Hajdusits & Darja Kordic & Erna Suljic & A, 2021. "Multiplexed detection of SARS-CoV-2 and other respiratory infections in high throughput by SARSeq," Nature Communications, Nature, vol. 12(1), pages 1-17, December.
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