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Heparin-network-mediated long-lasting coatings on intravascular catheters for adaptive antithrombosis and antibacterial infection

Author

Listed:
  • Lin Liu

    (Chinese Academy of Sciences
    University of Science and Technology of China)

  • Huan Yu

    (Chinese Academy of Sciences
    University of Science and Technology of China)

  • Lei Wang

    (Chinese Academy of Sciences)

  • Dongfang Zhou

    (Southern Medical University)

  • Xiaozheng Duan

    (Chinese Academy of Sciences)

  • Xu Zhang

    (Chinese Academy of Sciences)

  • Jinghua Yin

    (Chinese Academy of Sciences)

  • Shifang Luan

    (Chinese Academy of Sciences
    University of Science and Technology of China)

  • Hengchong Shi

    (Chinese Academy of Sciences
    University of Science and Technology of China)

Abstract

Bacteria-associated infections and thrombosis, particularly catheter-related bloodstream infections and catheter-related thrombosis, are life-threatening complications. Herein, we utilize a concise assembly of heparin sodium with organosilicon quaternary ammonium surfactant to fabricate a multifunctional coating complex. In contrast to conventional one-time coatings, the complex attaches to medical devices with arbitrary shapes and compositions through a facile dipping process and further forms robust coatings to treat catheter-related bloodstream infections and thrombosis simultaneously. Through their robustness and adaptively dissociation, coatings not only exhibit good stability under extreme conditions but also significantly reduce thrombus adhesion by 60%, and shows broad-spectrum antibacterial activity ( > 97%) in vitro and in vivo. Furthermore, an ex vivo rabbit model verifies that the coated catheter has the potential to prevent catheter-related bacteremia during implantation. This substrate-independent and portable long-lasting multifunctional coating can be employed to meet the increasing clinical demands for combating catheter-related bloodstream infections and thrombosis.

Suggested Citation

  • Lin Liu & Huan Yu & Lei Wang & Dongfang Zhou & Xiaozheng Duan & Xu Zhang & Jinghua Yin & Shifang Luan & Hengchong Shi, 2024. "Heparin-network-mediated long-lasting coatings on intravascular catheters for adaptive antithrombosis and antibacterial infection," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44478-3
    DOI: 10.1038/s41467-023-44478-3
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    References listed on IDEAS

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    1. Mengmeng Yao & Zhijian Wei & Junjin Li & Zhicheng Guo & Zhuojun Yan & Xia Sun & Qingyu Yu & Xiaojun Wu & Chaojie Yu & Fanglian Yao & Shiqing Feng & Hong Zhang & Junjie Li, 2022. "Microgel reinforced zwitterionic hydrogel coating for blood-contacting biomedical devices," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
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