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Microgel reinforced zwitterionic hydrogel coating for blood-contacting biomedical devices

Author

Listed:
  • Mengmeng Yao

    (Tianjin University
    Tianjin University)

  • Zhijian Wei

    (Tianjin Medical University General Hospital
    Shandong University
    Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University)

  • Junjin Li

    (Tianjin Medical University General Hospital
    Shandong University
    Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University)

  • Zhicheng Guo

    (Tianjin University)

  • Zhuojun Yan

    (Tianjin University)

  • Xia Sun

    (Tianjin University)

  • Qingyu Yu

    (Tianjin University)

  • Xiaojun Wu

    (Tianjin University)

  • Chaojie Yu

    (Tianjin University)

  • Fanglian Yao

    (Tianjin University
    Tianjin University
    East China Jiaotong University)

  • Shiqing Feng

    (Tianjin Medical University General Hospital
    Shandong University
    Shandong University Centre for Orthopaedics, Cheeloo College of Medicine, Shandong University)

  • Hong Zhang

    (Tianjin University
    Tianjin University)

  • Junjie Li

    (Tianjin University
    Tianjin University)

Abstract

Zwitterionic hydrogels exhibit eminent nonfouling and hemocompatibility. Several key challenges hinder their application as coating materials for blood-contacting biomedical devices, including weak mechanical strength and low adhesion to the substrate. Here, we report a poly(carboxybetaine) microgel reinforced poly(sulfobetaine) (pCBM/pSB) pure zwitterionic hydrogel with excellent mechanical robustness and anti-swelling properties. The pCBM/pSB hydrogel coating was bonded to the PVC substrate via the entanglement network between the pSB and PVC chain. Moreover, the pCBM/pSB hydrogel coating can maintain favorable stability even after 21 d PBS shearing, 0.5 h strong water flushing, 1000 underwater bends, and 100 sandpaper abrasions. Notably, the pCBM/pSB hydrogel coated PVC tubing can not only mitigate the foreign body response but also prevent thrombus formation ex vivo in rats and rabbits blood circulation without anticoagulants. This work provides new insights to guide the design of pure zwitterionic hydrogel coatings for biomedical devices.

Suggested Citation

  • Mengmeng Yao & Zhijian Wei & Junjin Li & Zhicheng Guo & Zhuojun Yan & Xia Sun & Qingyu Yu & Xiaojun Wu & Chaojie Yu & Fanglian Yao & Shiqing Feng & Hong Zhang & Junjie Li, 2022. "Microgel reinforced zwitterionic hydrogel coating for blood-contacting biomedical devices," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33081-7
    DOI: 10.1038/s41467-022-33081-7
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    References listed on IDEAS

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    1. Hyunwoo Yuk & Teng Zhang & German Alberto Parada & Xinyue Liu & Xuanhe Zhao, 2016. "Skin-inspired hydrogel–elastomer hybrids with robust interfaces and functional microstructures," Nature Communications, Nature, vol. 7(1), pages 1-11, November.
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    1. Yuxuan Yang & Xiaodan Zhao & Shuang Wang & Yanfeng Zhang & Aiming Yang & Yilong Cheng & Xuesi Chen, 2023. "Ultra-durable cell-free bioactive hydrogel with fast shape memory and on-demand drug release for cartilage regeneration," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    2. Zhao Pan & Qi-Qi Fu & Mo-Han Wang & Huai-Ling Gao & Liang Dong & Pu Zhou & Dong-Dong Cheng & Ying Chen & Duo-Hong Zou & Jia-Cai He & Xue Feng & Shu-Hong Yu, 2023. "Designing nanohesives for rapid, universal, and robust hydrogel adhesion," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    3. Lin Liu & Huan Yu & Lei Wang & Dongfang Zhou & Xiaozheng Duan & Xu Zhang & Jinghua Yin & Shifang Luan & Hengchong Shi, 2024. "Heparin-network-mediated long-lasting coatings on intravascular catheters for adaptive antithrombosis and antibacterial infection," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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