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Ultra-durable cell-free bioactive hydrogel with fast shape memory and on-demand drug release for cartilage regeneration

Author

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  • Yuxuan Yang

    (Xi’an Jiaotong University)

  • Xiaodan Zhao

    (Xi’an Jiaotong University)

  • Shuang Wang

    (Xi’an Jiaotong University)

  • Yanfeng Zhang

    (Xi’an Jiaotong University)

  • Aiming Yang

    (The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an Jiaotong University)

  • Yilong Cheng

    (Xi’an Jiaotong University
    The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an Jiaotong University)

  • Xuesi Chen

    (Chinese Academy of Sciences)

Abstract

Osteoarthritis is a worldwide prevalent disease that imposes a significant socioeconomic burden on individuals and healthcare systems. Achieving cartilage regeneration in patients with osteoarthritis remains challenging clinically. In this work, we construct a multiple hydrogen-bond crosslinked hydrogel loaded with tannic acid and Kartogenin by polyaddition reaction as a cell-free scaffold for in vivo cartilage regeneration, which features ultra-durable mechanical properties and stage-dependent drug release behavior. We demonstrate that the hydrogel can withstand 28000 loading-unloading mechanical cycles and exhibits fast shape memory at body temperature (30 s) with the potential for minimally invasive surgery. We find that the hydrogel can also alleviate the inflammatory reaction and regulate oxidative stress in situ to establish a microenvironment conducive to healing. We show that the sequential release of tannic acid and Kartogenin can promote the migration of bone marrow mesenchymal stem cells into the hydrogel scaffold, followed by the induction of chondrocyte differentiation, thus leading to full-thickness cartilage regeneration in vivo. This work may provide a promising solution to address the problem of cartilage regeneration.

Suggested Citation

  • Yuxuan Yang & Xiaodan Zhao & Shuang Wang & Yanfeng Zhang & Aiming Yang & Yilong Cheng & Xuesi Chen, 2023. "Ultra-durable cell-free bioactive hydrogel with fast shape memory and on-demand drug release for cartilage regeneration," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43334-8
    DOI: 10.1038/s41467-023-43334-8
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    1. Mengmeng Yao & Zhijian Wei & Junjin Li & Zhicheng Guo & Zhuojun Yan & Xia Sun & Qingyu Yu & Xiaojun Wu & Chaojie Yu & Fanglian Yao & Shiqing Feng & Hong Zhang & Junjie Li, 2022. "Microgel reinforced zwitterionic hydrogel coating for blood-contacting biomedical devices," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
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