IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-023-44330-8.html
   My bibliography  Save this article

Protection against symptomatic dengue infection by neutralizing antibodies varies by infection history and infecting serotype

Author

Listed:
  • Sandra Bos

    (University of California, Berkeley)

  • Aaron L. Graber

    (University of California, Berkeley)

  • Jaime A. Cardona-Ospina

    (University of California, Berkeley
    Facultad de Medicina, Institución Universitaria Visión de las Américas)

  • Elias M. Duarte

    (University of California, Berkeley)

  • Jose Victor Zambrana

    (Sustainable Sciences Institute
    University of Michigan)

  • Jorge A. Ruíz Salinas

    (Sustainable Sciences Institute)

  • Reinaldo Mercado-Hernandez

    (University of California, Berkeley)

  • Tulika Singh

    (University of California, Berkeley)

  • Leah C. Katzelnick

    (National Institute of Allergy and Infectious Diseases, National Institutes of Health)

  • Aravinda Silva

    (University of North Carolina)

  • Guillermina Kuan

    (Sustainable Sciences Institute
    Centro de Salud Sócrates Flores Vivas, Ministerio de Salud)

  • Angel Balmaseda

    (Sustainable Sciences Institute
    Laboratorio Nacional de Virología, Centro Nacional de Diagnóstico y Referencia, Ministerio de Salud)

  • Eva Harris

    (University of California, Berkeley)

Abstract

Dengue viruses (DENV1–4) are the most prevalent arboviruses in humans and a major public health concern. Understanding immune mechanisms that modulate DENV infection outcome is critical for vaccine development. Neutralizing antibodies (nAbs) are an essential component of the protective immune response, yet their measurement often relies on a single cellular substrate and partially mature virions, which does not capture the full breadth of neutralizing activity and may lead to biased estimations of nAb potency. Here, we analyze 125 samples collected after one or more DENV infections but prior to subsequent symptomatic or inapparent DENV1, DENV2, or DENV3 infections from a long-standing pediatric cohort study in Nicaragua. By assessing nAb responses using Vero cells with or without DC-SIGN and with mature or partially mature virions, we find that nAb potency and the protective NT50 cutoff are greatly influenced by cell substrate and virion maturation state. Additionally, the correlation between nAb titer and protection from disease depends on prior infection history and infecting serotype. Finally, we uncover variations in nAb composition that contribute to protection from symptomatic infection differently after primary and secondary prior infection. These findings have important implications for identifying antibody correlates of protection for vaccines and natural infections.

Suggested Citation

  • Sandra Bos & Aaron L. Graber & Jaime A. Cardona-Ospina & Elias M. Duarte & Jose Victor Zambrana & Jorge A. Ruíz Salinas & Reinaldo Mercado-Hernandez & Tulika Singh & Leah C. Katzelnick & Aravinda Silv, 2024. "Protection against symptomatic dengue infection by neutralizing antibodies varies by infection history and infecting serotype," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44330-8
    DOI: 10.1038/s41467-023-44330-8
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-44330-8
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-023-44330-8?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Henrik Salje & Derek A. T. Cummings & Isabel Rodriguez-Barraquer & Leah C. Katzelnick & Justin Lessler & Chonticha Klungthong & Butsaya Thaisomboonsuk & Ananda Nisalak & Alden Weg & Damon Ellison & Lo, 2018. "Reconstruction of antibody dynamics and infection histories to evaluate dengue risk," Nature, Nature, vol. 557(7707), pages 719-723, May.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ruopeng Xie & Kimberly M. Edwards & Dillon C. Adam & Kathy S. M. Leung & Tim K. Tsang & Shreya Gurung & Weijia Xiong & Xiaoman Wei & Daisy Y. M. Ng & Gigi Y. Z. Liu & Pavithra Krishnan & Lydia D. J. C, 2023. "Resurgence of Omicron BA.2 in SARS-CoV-2 infection-naive Hong Kong," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Hay, James & Routledge, Isobel & Takahashi, Saki, 2023. "Serodynamics: a review of methods for epidemiological inference using serological data," OSF Preprints kqdsn, Center for Open Science.
    3. Yun Lin & Bingyi Yang & Sarah Cobey & Eric H. Y. Lau & Dillon C. Adam & Jessica Y. Wong & Helen S. Bond & Justin K. Cheung & Faith Ho & Huizhi Gao & Sheikh Taslim Ali & Nancy H. L. Leung & Tim K. Tsan, 2022. "Incorporating temporal distribution of population-level viral load enables real-time estimation of COVID-19 transmission," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    4. Tim K. Tsang & Ranawaka A. P. M. Perera & Vicky J. Fang & Jessica Y. Wong & Eunice Y. Shiu & Hau Chi So & Dennis K. M. Ip & J. S. Malik Peiris & Gabriel M. Leung & Benjamin J. Cowling & Simon Caucheme, 2022. "Reconstructing antibody dynamics to estimate the risk of influenza virus infection," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    5. Rúbens Prince dos Santos Alves & Julia Timis & Robyn Miller & Kristen Valentine & Paolla Beatriz Almeida Pinto & Andrew Gonzalez & Jose Angel Regla-Nava & Erin Maule & Michael N. Nguyen & Norazizah Sh, 2024. "Human coronavirus OC43-elicited CD4+ T cells protect against SARS-CoV-2 in HLA transgenic mice," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    6. Nathanaël Hozé & Issa Diarra & Abdoul Karim Sangaré & Boris Pastorino & Laura Pezzi & Bourèma Kouriba & Issaka Sagara & Abdoulaye Dabo & Abdoulaye Djimdé & Mahamadou Ali Thera & Ogobara K. Doumbo & Xa, 2021. "Model-based assessment of Chikungunya and O’nyong-nyong virus circulation in Mali in a serological cross-reactivity context," Nature Communications, Nature, vol. 12(1), pages 1-9, December.
    7. Ellen Young & Boyd Yount & Petraleigh Pantoja & Sandra Henein & Rita M. Meganck & Jennifer McBride & Jennifer E. Munt & Thomas J. Baric & Deanna Zhu & Trevor Scobey & Stephanie Dong & Longping V. Tse , 2023. "A live dengue virus vaccine carrying a chimeric envelope glycoprotein elicits dual DENV2-DENV4 serotype-specific immunity," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44330-8. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.