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Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis

Author

Listed:
  • Yunxuan Lei

    (Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology)

  • Xin Guo

    (Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology)

  • Yanping Luo

    (Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology)

  • Xiaoyin Niu

    (Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology)

  • Yebin Xi

    (Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology)

  • Lianbo Xiao

    (Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine
    Institute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine)

  • Dongyi He

    (Institute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine
    Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine)

  • Yanqin Bian

    (Institute of Arthritis Research in Integrative Medicine, Shanghai Academy of Traditional Chinese Medicine)

  • Yong Zhang

    (Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology)

  • Li Wang

    (Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology)

  • Xiaochun Peng

    (Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine)

  • Zhaojun Wang

    (Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology)

  • Guangjie Chen

    (Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Immunology)

Abstract

Mast cells are phenotypically and functionally heterogeneous, and their state is possibly controlled by local microenvironment. Therefore, specific analyses are needed to understand whether mast cells function as powerful participants or dispensable bystanders in specific diseases. Here, we show that degranulation of mast cells in inflammatory synovial tissues of patients with rheumatoid arthritis (RA) is induced via MAS-related G protein-coupled receptor X2 (MRGPRX2), and the expression of MHC class II and costimulatory molecules on mast cells are upregulated. Collagen-induced arthritis mice treated with a combination of anti-IL-17A and cromolyn sodium, a mast cell membrane stabilizer, show significantly reduced clinical severity and decreased bone erosion. The findings of the present study suggest that synovial microenvironment-influenced mast cells contribute to disease progression and may provide a further mast cell-targeting therapy for RA.

Suggested Citation

  • Yunxuan Lei & Xin Guo & Yanping Luo & Xiaoyin Niu & Yebin Xi & Lianbo Xiao & Dongyi He & Yanqin Bian & Yong Zhang & Li Wang & Xiaochun Peng & Zhaojun Wang & Guangjie Chen, 2024. "Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-44304-w
    DOI: 10.1038/s41467-023-44304-w
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    References listed on IDEAS

    as
    1. Régis Joulia & Nicolas Gaudenzio & Magda Rodrigues & Jodie Lopez & Nicolas Blanchard & Salvatore Valitutti & Eric Espinosa, 2015. "Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence," Nature Communications, Nature, vol. 6(1), pages 1-12, May.
    2. Fan Yang & Lulu Guo & Yu Li & Guopeng Wang & Jia Wang & Chao Zhang & Guo-Xing Fang & Xu Chen & Lei Liu & Xu Yan & Qun Liu & Changxiu Qu & Yunfei Xu & Peng Xiao & Zhongliang Zhu & Zijian Li & Jiuyao Zh, 2021. "Structure, function and pharmacology of human itch receptor complexes," Nature, Nature, vol. 600(7887), pages 164-169, December.
    3. Can Cao & Hye Jin Kang & Isha Singh & He Chen & Chengwei Zhang & Wenlei Ye & Byron W. Hayes & Jing Liu & Ryan H. Gumpper & Brian J. Bender & Samuel T. Slocum & Brian E. Krumm & Katherine Lansu & John , 2021. "Structure, function and pharmacology of human itch GPCRs," Nature, Nature, vol. 600(7887), pages 170-175, December.
    4. Moritz F. Eissmann & Christine Dijkstra & Andrew Jarnicki & Toby Phesse & Jamina Brunnberg & Ashleigh R. Poh & Nima Etemadi & Evelyn Tsantikos & Stefan Thiem & Nicholas D. Huntington & Margaret L. Hib, 2019. "IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization," Nature Communications, Nature, vol. 10(1), pages 1-16, December.
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