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Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence

Author

Listed:
  • Régis Joulia

    (Inserm, U1043, Toulouse F-31300, France; Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP))

  • Nicolas Gaudenzio

    (Inserm, U1043, Toulouse F-31300, France; Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP)
    Present address: Department of Pathology, School of Medicine, Stanford University, Stanford, California 94305-5176, USA)

  • Magda Rodrigues

    (Inserm, U1043, Toulouse F-31300, France; Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP))

  • Jodie Lopez

    (Inserm, U1043, Toulouse F-31300, France; Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP))

  • Nicolas Blanchard

    (Inserm, U1043, Toulouse F-31300, France; Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP))

  • Salvatore Valitutti

    (Inserm, U1043, Toulouse F-31300, France; Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP))

  • Eric Espinosa

    (Inserm, U1043, Toulouse F-31300, France; Université de Toulouse, UPS, Centre de Physiopathologie de Toulouse Purpan (CPTP))

Abstract

Mast cells are tissue-resident immune cells that play a key role in inflammation and allergy. Here we show that interaction of mast cells with antibody-targeted cells induces the polarized exocytosis of their granules resulting in a sustained exposure of effector enzymes, such as tryptase and chymase, at the cell–cell contact site. This previously unidentified mast cell effector mechanism, which we name the antibody-dependent degranulatory synapse (ADDS), is triggered by both IgE- and IgG-targeted cells. ADDSs take place within an area of cortical actin cytoskeleton clearance in the absence of microtubule organizing centre and Golgi apparatus repositioning towards the stimulating cell. Remarkably, IgG-mediated degranulatory synapses also occur upon contact with opsonized Toxoplasma gondii tachyzoites resulting in tryptase-dependent parasite death. Our results broaden current views of mast cell degranulation by revealing that human mast cells form degranulatory synapses with antibody-targeted cells and pathogens for dedicated secretion and defence.

Suggested Citation

  • Régis Joulia & Nicolas Gaudenzio & Magda Rodrigues & Jodie Lopez & Nicolas Blanchard & Salvatore Valitutti & Eric Espinosa, 2015. "Mast cells form antibody-dependent degranulatory synapse for dedicated secretion and defence," Nature Communications, Nature, vol. 6(1), pages 1-12, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7174
    DOI: 10.1038/ncomms7174
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    Cited by:

    1. Yunxuan Lei & Xin Guo & Yanping Luo & Xiaoyin Niu & Yebin Xi & Lianbo Xiao & Dongyi He & Yanqin Bian & Yong Zhang & Li Wang & Xiaochun Peng & Zhaojun Wang & Guangjie Chen, 2024. "Synovial microenvironment-influenced mast cells promote the progression of rheumatoid arthritis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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