Genome-wide mutational signatures in low-coverage whole genome sequencing of cell-free DNA
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DOI: 10.1038/s41467-022-32598-1
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- Viktor A. Adalsteinsson & Gavin Ha & Samuel S. Freeman & Atish D. Choudhury & Daniel G. Stover & Heather A. Parsons & Gregory Gydush & Sarah C. Reed & Denisse Rotem & Justin Rhoades & Denis Loginov & , 2017. "Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors," Nature Communications, Nature, vol. 8(1), pages 1-13, December.
- Kenichi Yoshida & Kate H. C. Gowers & Henry Lee-Six & Deepak P. Chandrasekharan & Tim Coorens & Elizabeth F. Maughan & Kathryn Beal & Andrew Menzies & Fraser R. Millar & Elizabeth Anderson & Sarah E. , 2020. "Tobacco smoking and somatic mutations in human bronchial epithelium," Nature, Nature, vol. 578(7794), pages 266-272, February.
- Ludmil B. Alexandrov & Jaegil Kim & Nicholas J. Haradhvala & Mi Ni Huang & Alvin Wei Tian Ng & Yang Wu & Arnoud Boot & Kyle R. Covington & Dmitry A. Gordenin & Erik N. Bergstrom & S. M. Ashiqul Islam , 2020. "The repertoire of mutational signatures in human cancer," Nature, Nature, vol. 578(7793), pages 94-101, February.
- Ruoyan Li & Lin Di & Jie Li & Wenyi Fan & Yachen Liu & Wenjia Guo & Weiling Liu & Lu Liu & Qiong Li & Liping Chen & Yamei Chen & Chuanwang Miao & Hongjin Liu & Yuqian Wang & Yuling Ma & Deshu Xu & Don, 2021. "A body map of somatic mutagenesis in morphologically normal human tissues," Nature, Nature, vol. 597(7876), pages 398-403, September.
- Henry Lee-Six & Sigurgeir Olafsson & Peter Ellis & Robert J. Osborne & Mathijs A. Sanders & Luiza Moore & Nikitas Georgakopoulos & Franco Torrente & Ayesha Noorani & Martin Goddard & Philip Robinson &, 2019. "The landscape of somatic mutation in normal colorectal epithelial cells," Nature, Nature, vol. 574(7779), pages 532-537, October.
- Jacob J. Chabon & Emily G. Hamilton & David M. Kurtz & Mohammad S. Esfahani & Everett J. Moding & Henning Stehr & Joseph Schroers-Martin & Barzin Y. Nabet & Binbin Chen & Aadel A. Chaudhuri & Chih Lon, 2020. "Integrating genomic features for non-invasive early lung cancer detection," Nature, Nature, vol. 580(7802), pages 245-251, April.
- Federico Abascal & Luke M. R. Harvey & Emily Mitchell & Andrew R. J. Lawson & Stefanie V. Lensing & Peter Ellis & Andrew J. C. Russell & Raul E. Alcantara & Adrian Baez-Ortega & Yichen Wang & Eugene J, 2021. "Somatic mutation landscapes at single-molecule resolution," Nature, Nature, vol. 593(7859), pages 405-410, May.
- Luiza Moore & Alex Cagan & Tim H. H. Coorens & Matthew D. C. Neville & Rashesh Sanghvi & Mathijs A. Sanders & Thomas R. W. Oliver & Daniel Leongamornlert & Peter Ellis & Ayesha Noorani & Thomas J. Mit, 2021. "The mutational landscape of human somatic and germline cells," Nature, Nature, vol. 597(7876), pages 381-386, September.
- Andrius Vabalas & Emma Gowen & Ellen Poliakoff & Alexander J Casson, 2019. "Machine learning algorithm validation with a limited sample size," PLOS ONE, Public Library of Science, vol. 14(11), pages 1-20, November.
- Stephen Cristiano & Alessandro Leal & Jillian Phallen & Jacob Fiksel & Vilmos Adleff & Daniel C. Bruhm & Sarah Østrup Jensen & Jamie E. Medina & Carolyn Hruban & James R. White & Doreen N. Palsgrove &, 2019. "Genome-wide cell-free DNA fragmentation in patients with cancer," Nature, Nature, vol. 570(7761), pages 385-389, June.
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