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Metallopolymer strategy to explore hypoxic active narrow-bandgap photosensitizers for effective cancer photodynamic therapy

Author

Listed:
  • Zhao Zhang

    (University of Macau)

  • Zixiang Wei

    (University of Macau)

  • Jintong Guo

    (University of Macau)

  • Jinxiao Lyu

    (University of Macau)

  • Bingzhe Wang

    (University of Macau)

  • Gang Wang

    (University of Macau)

  • Chunfei Wang

    (University of Macau)

  • Liqiang Zhou

    (University of Macau
    University of Macau)

  • Zhen Yuan

    (University of Macau
    University of Macau)

  • Guichuan Xing

    (University of Macau)

  • Changfeng Wu

    (Southern University of Science and Technology)

  • Xuanjun Zhang

    (University of Macau
    University of Macau)

Abstract

Practical photodynamic therapy calls for high-performance, less O2-dependent, long-wavelength-light-activated photosensitizers to suit the hypoxic tumor microenvironment. Iridium-based photosensitizers exhibit excellent photocatalytic performance, but the in vivo applications are hindered by conventional O2-dependent Type-II photochemistry and poor absorption. Here we show a general metallopolymerization strategy for engineering iridium complexes exhibiting Type-I photochemistry and enhancing absorption intensity in the blue to near-infrared region. Reactive oxygen species generation of metallopolymer Ir-P1, where the iridium atom is covalently coupled to the polymer backbone, is over 80 times higher than that of its mother polymer without iridium under 680 nm irradiation. This strategy also works effectively when the iridium atom is directly included (Ir-P2) in the polymer backbones, exhibiting wide generality. The metallopolymer nanoparticles exhibiting efficient O2•− generation are conjugated with integrin αvβ3 binding cRGD to achieve targeted photodynamic therapy.

Suggested Citation

  • Zhao Zhang & Zixiang Wei & Jintong Guo & Jinxiao Lyu & Bingzhe Wang & Gang Wang & Chunfei Wang & Liqiang Zhou & Zhen Yuan & Guichuan Xing & Changfeng Wu & Xuanjun Zhang, 2024. "Metallopolymer strategy to explore hypoxic active narrow-bandgap photosensitizers for effective cancer photodynamic therapy," Nature Communications, Nature, vol. 15(1), pages 1-14, December.
  • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-023-43890-z
    DOI: 10.1038/s41467-023-43890-z
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    References listed on IDEAS

    as
    1. Jing An & Shanliang Tang & Gaobo Hong & Wenlong Chen & Miaomiao Chen & Jitao Song & Zhiliang Li & Xiaojun Peng & Fengling Song & Wen-Heng Zheng, 2022. "An unexpected strategy to alleviate hypoxia limitation of photodynamic therapy by biotinylation of photosensitizers," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    2. Kun-Xu Teng & Li-Ya Niu & Nan Xie & Qing-Zheng Yang, 2022. "Supramolecular photodynamic agents for simultaneous oxidation of NADH and generation of superoxide radical," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    3. Chaiheon Lee & Jung Seung Nam & Chae Gyu Lee & Mingyu Park & Chang-Mo Yoo & Hyun-Woo Rhee & Jeong Kon Seo & Tae-Hyuk Kwon, 2021. "Analysing the mechanism of mitochondrial oxidation-induced cell death using a multifunctional iridium(III) photosensitiser," Nature Communications, Nature, vol. 12(1), pages 1-11, December.
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