IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-43645-w.html
   My bibliography  Save this article

CXCL12 targets the primary cilium cAMP/cGMP ratio to regulate cell polarity during migration

Author

Listed:
  • Melody Atkins

    (Sorbonne Université)

  • Maud Wurmser

    (Sorbonne Université, INSERM CNRS)

  • Michèle Darmon

    (Sorbonne Université)

  • Fiona Roche

    (Sorbonne Université, INSERM CNRS)

  • Xavier Nicol

    (Sorbonne Université, INSERM CNRS)

  • Christine Métin

    (Sorbonne Université)

Abstract

Directed cell migration requires sustained cell polarisation. In migrating cortical interneurons, nuclear movements are directed towards the centrosome that organises the primary cilium signalling hub. Primary cilium-elicited signalling, and how it affects migration, remain however ill characterised. Here, we show that altering cAMP/cGMP levels in the primary cilium by buffering cAMP, cGMP or by locally increasing cAMP, influences the polarity and directionality of migrating interneurons, whereas buffering cAMP or cGMP in the apposed centrosome compartment alters their motility. Remarkably, we identify CXCL12 as a trigger that targets the ciliary cAMP/cGMP ratio to promote sustained polarity and directed migration. We thereby uncover cAMP/cGMP levels in the primary cilium as a major target of extrinsic cues and as the steering wheel of neuronal migration.

Suggested Citation

  • Melody Atkins & Maud Wurmser & Michèle Darmon & Fiona Roche & Xavier Nicol & Christine Métin, 2023. "CXCL12 targets the primary cilium cAMP/cGMP ratio to regulate cell polarity during migration," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43645-w
    DOI: 10.1038/s41467-023-43645-w
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-43645-w
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-43645-w?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Makoto Nishiyama & Akemi Hoshino & Lily Tsai & John R. Henley & Yoshio Goshima & Marc Tessier-Lavigne & Mu-ming Poo & Kyonsoo Hong, 2003. "Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning," Nature, Nature, vol. 423(6943), pages 990-995, June.
    2. Stefania Averaimo & Ahlem Assali & Oriol Ros & Sandrine Couvet & Yvrick Zagar & Ioana Genescu & Alexandra Rebsam & Xavier Nicol, 2016. "A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors," Nature Communications, Nature, vol. 7(1), pages 1-12, November.
    3. Sarah Baudet & Yvrick Zagar & Fiona Roche & Claudia Gomez-Bravo & Sandrine Couvet & Johann Bécret & Morgane Belle & Juliette Vougny & Sinthuya Uthayasuthan & Oriol Ros & Xavier Nicol, 2023. "Subcellular second messenger networks drive distinct repellent-induced axon behaviors," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Franck Polleux & Theresa Morrow & Anirvan Ghosh, 2000. "Semaphorin 3A is a chemoattractant for cortical apical dendrites," Nature, Nature, vol. 404(6778), pages 567-573, April.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Charles Petitpré & Louis Faure & Phoebe Uhl & Paula Fontanet & Iva Filova & Gabriela Pavlinkova & Igor Adameyko & Saida Hadjab & Francois Lallemend, 2022. "Single-cell RNA-sequencing analysis of the developing mouse inner ear identifies molecular logic of auditory neuron diversification," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Sarah Baudet & Yvrick Zagar & Fiona Roche & Claudia Gomez-Bravo & Sandrine Couvet & Johann Bécret & Morgane Belle & Juliette Vougny & Sinthuya Uthayasuthan & Oriol Ros & Xavier Nicol, 2023. "Subcellular second messenger networks drive distinct repellent-induced axon behaviors," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    3. Mattia Zaghi & Federica Banfi & Luca Massimino & Monica Volpin & Edoardo Bellini & Simone Brusco & Ivan Merelli & Cristiana Barone & Michela Bruni & Linda Bossini & Luigi Antonio Lamparelli & Laura Pi, 2023. "Balanced SET levels favor the correct enhancer repertoire during cell fate acquisition," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    4. Léa Ripoll & Yong Li & Carmen W. Dessauer & Mark Zastrow, 2024. "Spatial organization of adenylyl cyclase and its impact on dopamine signaling in neurons," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43645-w. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.