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Health-related quality of life is linked to the gut microbiome in kidney transplant recipients

Author

Listed:
  • J. Casper Swarte

    (University of Groningen, University Medical Center Groningen
    University of Groningen, University Medical Center Groningen)

  • Tim J. Knobbe

    (University of Groningen, University Medical Center Groningen)

  • Johannes R. Björk

    (University of Groningen, University Medical Center Groningen
    University of Groningen, University Medical Center Groningen)

  • Ranko Gacesa

    (University of Groningen, University Medical Center Groningen
    University of Groningen, University Medical Center Groningen)

  • Lianne M. Nieuwenhuis

    (University of Groningen, University Medical Center Groningen)

  • Shuyan Zhang

    (University of Groningen, University Medical Center Groningen)

  • Arnau Vich Vila

    (University of Groningen, University Medical Center Groningen
    University of Groningen, University Medical Center Groningen)

  • Daan Kremer

    (University of Groningen, University Medical Center Groningen)

  • Rianne M. Douwes

    (University of Groningen, University Medical Center Groningen
    University of Groningen, University Medical Center Groningen)

  • Adrian Post

    (University of Groningen, University Medical Center Groningen)

  • Evelien E. Quint

    (University of Groningen, University Medical Center Groningen)

  • Robert A. Pol

    (University of Groningen, University Medical Center Groningen)

  • Bernadien H. Jansen

    (University of Groningen, University Medical Center Groningen)

  • Martin H. Borst

    (University of Groningen, University Medical Center Groningen)

  • Vincent E. Meijer

    (University of Groningen, University Medical Center Groningen)

  • Hans Blokzijl

    (University of Groningen, University Medical Center Groningen)

  • Stefan P. Berger

    (University of Groningen, University Medical Center Groningen)

  • Eleonora A. M. Festen

    (University of Groningen, University Medical Center Groningen
    University of Groningen, University Medical Center Groningen)

  • Alexandra Zhernakova

    (University of Groningen, University Medical Center Groningen)

  • Jingyuan Fu

    (University of Groningen, University Medical Center Groningen
    University of Groningen, University Medical Center Groningen)

  • Hermie J. M. Harmsen

    (University of Groningen, University Medical Center Groningen)

  • Stephan J. L. Bakker

    (University of Groningen, University Medical Center Groningen)

  • Rinse K. Weersma

    (University of Groningen, University Medical Center Groningen)

Abstract

Kidney transplant recipients (KTR) have impaired health-related quality of life (HRQoL) and suffer from intestinal dysbiosis. Increasing evidence shows that gut health and HRQoL are tightly related in the general population. Here, we investigate the association between the gut microbiome and HRQoL in KTR, using metagenomic sequencing data from fecal samples collected from 507 KTR. Multiple bacterial species are associated with lower HRQoL, many of which have previously been associated with adverse health conditions. Gut microbiome distance to the general population is highest among KTR with an impaired physical HRQoL (R = −0.20, P = 2.3 × 10−65) and mental HRQoL (R = −0.14, P = 1.3 × 10−3). Physical and mental HRQoL explain a significant part of variance in the gut microbiome (R2 = 0.58%, FDR = 5.43 × 10−4 and R2 = 0.37%, FDR = 1.38 × 10−3, respectively). Additionally, multiple metabolic and neuroactive pathways (gut brain modules) are associated with lower HRQoL. While the observational design of our study does not allow us to analyze causality, we provide a comprehensive overview of the associations between the gut microbiome and HRQoL while controlling for confounders.

Suggested Citation

  • J. Casper Swarte & Tim J. Knobbe & Johannes R. Björk & Ranko Gacesa & Lianne M. Nieuwenhuis & Shuyan Zhang & Arnau Vich Vila & Daan Kremer & Rianne M. Douwes & Adrian Post & Evelien E. Quint & Robert , 2023. "Health-related quality of life is linked to the gut microbiome in kidney transplant recipients," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43431-8
    DOI: 10.1038/s41467-023-43431-8
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    References listed on IDEAS

    as
    1. R. Gacesa & A. Kurilshikov & A. Vich Vila & T. Sinha & M. A. Y. Klaassen & L. A. Bolte & S. Andreu-Sánchez & L. Chen & V. Collij & S. Hu & J. A. M. Dekens & V. C. Lenters & J. R. Björk & J. C. Swarte , 2022. "Environmental factors shaping the gut microbiome in a Dutch population," Nature, Nature, vol. 604(7907), pages 732-739, April.
    2. J. de Sousa & K. Hron & K. Fačevicová & P. Filzmoser, 2021. "Robust principal component analysis for compositional tables," Journal of Applied Statistics, Taylor & Francis Journals, vol. 48(2), pages 214-233, January.
    3. Yu-Kang Mao & Dennis L. Kasper & Bingxian Wang & Paul Forsythe & John Bienenstock & Wolfgang A. Kunze, 2013. "Bacteroides fragilis polysaccharide A is necessary and sufficient for acute activation of intestinal sensory neurons," Nature Communications, Nature, vol. 4(1), pages 1-10, June.
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