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Isochronic development of cortical synapses in primates and mice

Author

Listed:
  • Gregg Wildenberg

    (The University of Chicago
    Biosciences Division)

  • Hanyu Li

    (The University of Chicago
    Biosciences Division)

  • Vandana Sampathkumar

    (The University of Chicago
    Biosciences Division)

  • Anastasia Sorokina

    (The University of Chicago
    Biosciences Division)

  • Narayanan Kasthuri

    (The University of Chicago
    Biosciences Division)

Abstract

The neotenous, or delayed, development of primate neurons, particularly human ones, is thought to underlie primate-specific abilities like cognition. We tested whether synaptic development follows suit—would synapses, in absolute time, develop slower in longer-lived, highly cognitive species like non-human primates than in shorter-lived species with less human-like cognitive abilities, e.g., the mouse? Instead, we find that excitatory and inhibitory synapses in the male Mus musculus (mouse) and Rhesus macaque (primate) cortex form at similar rates, at similar times after birth. Primate excitatory and inhibitory synapses and mouse excitatory synapses also prune in such an isochronic fashion. Mouse inhibitory synapses are the lone exception, which are not pruned and instead continuously added throughout life. The monotony of synaptic development clocks across species with disparate lifespans, experiences, and cognitive abilities argues that such programs are likely orchestrated by genetic events rather than experience.

Suggested Citation

  • Gregg Wildenberg & Hanyu Li & Vandana Sampathkumar & Anastasia Sorokina & Narayanan Kasthuri, 2023. "Isochronic development of cortical synapses in primates and mice," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-43088-3
    DOI: 10.1038/s41467-023-43088-3
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    References listed on IDEAS

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    1. Yunfeng Hua & Philip Laserstein & Moritz Helmstaedter, 2015. "Large-volume en-bloc staining for electron microscopy-based connectomics," Nature Communications, Nature, vol. 6(1), pages 1-7, November.
    2. Michela Fagiolini & Takao K. Hensch, 2000. "Inhibitory threshold for critical-period activation in primary visual cortex," Nature, Nature, vol. 404(6774), pages 183-186, March.
    3. Simone Holler & German Köstinger & Kevan A. C. Martin & Gregor F. P. Schuhknecht & Ken J. Stratford, 2021. "Structure and function of a neocortical synapse," Nature, Nature, vol. 591(7848), pages 111-116, March.
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