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Diurnal changes in the efficiency of information transmission at a sensory synapse

Author

Listed:
  • José Moya-Díaz

    (University of Sussex)

  • Ben James

    (University of Sussex)

  • Federico Esposti

    (University of Sussex)

  • Jamie Johnston

    (University of Sussex)

  • Leon Lagnado

    (University of Sussex)

Abstract

Neuromodulators adapt sensory circuits to changes in the external world or the animal’s internal state and synapses are key control sites for such plasticity. Less clear is how neuromodulation alters the amount of information transmitted through the circuit. We investigated this question in the context of the diurnal regulation of visual processing in the retina of zebrafish, focusing on ribbon synapses of bipolar cells. We demonstrate that contrast-sensitivity peaks in the afternoon accompanied by a four-fold increase in the average Shannon information transmitted from an active zone. This increase reflects higher synaptic gain, lower spontaneous “noise” and reduced variability of evoked responses. Simultaneously, an increase in the probability of multivesicular events with larger information content increases the efficiency of transmission (bits per vesicle) by factors of 1.5-2.7. This study demonstrates the multiplicity of mechanisms by which a neuromodulator can adjust the synaptic transfer of sensory information.

Suggested Citation

  • José Moya-Díaz & Ben James & Federico Esposti & Jamie Johnston & Leon Lagnado, 2022. "Diurnal changes in the efficiency of information transmission at a sensory synapse," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-30202-0
    DOI: 10.1038/s41467-022-30202-0
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    References listed on IDEAS

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    1. Simone Holler & German Köstinger & Kevan A. C. Martin & Gregor F. P. Schuhknecht & Ken J. Stratford, 2021. "Structure and function of a neocortical synapse," Nature, Nature, vol. 591(7848), pages 111-116, March.
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