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Diurnal oscillations of MRI metrics in the brains of male participants

Author

Listed:
  • Matthew Carlucci

    (The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health
    Vilnius University)

  • Tristram Lett

    (Charité Universitätsmedizin Berlin)

  • Sofia Chavez

    (Centre for Addiction and Mental Health
    University of Toronto)

  • Alexandra Malinowski

    (The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health)

  • Nancy J. Lobaugh

    (Centre for Addiction and Mental Health
    University of Toronto)

  • Art Petronis

    (The Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health
    Vilnius University
    University of Toronto)

Abstract

Regulation of biological processes according to a 24-hr rhythm is essential for the normal functioning of an organism. Temporal variation in brain MRI data has often been attributed to circadian or diurnal oscillations; however, it is not clear if such oscillations exist. Here, we provide evidence that diurnal oscillations indeed govern multiple MRI metrics. We recorded cerebral blood flow, diffusion-tensor metrics, T1 relaxation, and cortical structural features every three hours over a 24-hr period in each of 16 adult male controls and eight adult male participants with bipolar disorder. Diurnal oscillations are detected in numerous MRI metrics at the whole-brain level, and regionally. Rhythmicity parameters in the participants with bipolar disorder are similar to the controls for most metrics, except for a larger phase variation in cerebral blood flow. The ubiquitous nature of diurnal oscillations has broad implications for neuroimaging studies and furthers our understanding of the dynamic nature of the human brain.

Suggested Citation

  • Matthew Carlucci & Tristram Lett & Sofia Chavez & Alexandra Malinowski & Nancy J. Lobaugh & Art Petronis, 2023. "Diurnal oscillations of MRI metrics in the brains of male participants," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42588-6
    DOI: 10.1038/s41467-023-42588-6
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    References listed on IDEAS

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    1. Matthew F. Glasser & Timothy S. Coalson & Emma C. Robinson & Carl D. Hacker & John Harwell & Essa Yacoub & Kamil Ugurbil & Jesper Andersson & Christian F. Beckmann & Mark Jenkinson & Stephen M. Smith , 2016. "A multi-modal parcellation of human cerebral cortex," Nature, Nature, vol. 536(7615), pages 171-178, August.
    2. Steven M. Reppert & David R. Weaver, 2002. "Coordination of circadian timing in mammals," Nature, Nature, vol. 418(6901), pages 935-941, August.
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