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Gut microbiota aggravates neutrophil extracellular traps-induced pancreatic injury in hypertriglyceridemic pancreatitis

Author

Listed:
  • Guanqun Li

    (The First Affiliated Hospital of Harbin Medical University
    Ministry of Education)

  • Liwei Liu

    (The First Affiliated Hospital of Harbin Medical University
    Ministry of Education)

  • Tianqi Lu

    (The First Affiliated Hospital of Harbin Medical University
    Ministry of Education)

  • Yuhang Sui

    (The First Affiliated Hospital of Harbin Medical University
    Ministry of Education)

  • Can Zhang

    (The First Affiliated Hospital of Harbin Medical University
    Ministry of Education)

  • Yongwei Wang

    (The First Affiliated Hospital of Harbin Medical University)

  • Tao Zhang

    (The First Affiliated Hospital of Harbin Medical University)

  • Yu Xie

    (The First Affiliated Hospital of Harbin Medical University)

  • Peng Xiao

    (The First Affiliated Hospital of Harbin Medical University)

  • Zhongjie Zhao

    (The First Affiliated Hospital of Harbin Medical University)

  • Chundong Cheng

    (The First Affiliated Hospital of Harbin Medical University)

  • Jisheng Hu

    (The First Affiliated Hospital of Harbin Medical University
    Ministry of Education)

  • Hongze Chen

    (The First Affiliated Hospital of Harbin Medical University
    Ministry of Education)

  • Dongbo Xue

    (The First Affiliated Hospital of Harbin Medical University)

  • Hua Chen

    (The First Affiliated Hospital of Harbin Medical University)

  • Gang Wang

    (The First Affiliated Hospital of Harbin Medical University)

  • Rui Kong

    (The First Affiliated Hospital of Harbin Medical University
    Ministry of Education)

  • Hongtao Tan

    (The First Affiliated Hospital of Harbin Medical University)

  • Xuewei Bai

    (The First Affiliated Hospital of Harbin Medical University)

  • Zhibo Li

    (The First Affiliated Hospital of Harbin Medical University)

  • Florencia McAllister

    (The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center
    The University of Texas MD Anderson Cancer Center)

  • Le Li

    (The First Affiliated Hospital of Harbin Medical University
    Ministry of Education)

  • Bei Sun

    (The First Affiliated Hospital of Harbin Medical University
    Ministry of Education)

Abstract

Hypertriglyceridemic pancreatitis (HTGP) is featured by higher incidence of complications and poor clinical outcomes. Gut microbiota dysbiosis is associated with pancreatic injury in HTGP and the mechanism remains unclear. Here, we observe lower diversity of gut microbiota and absence of beneficial bacteria in HTGP patients. In a fecal microbiota transplantation mouse model, the colonization of gut microbiota from HTGP patients recruits neutrophils and increases neutrophil extracellular traps (NETs) formation that exacerbates pancreatic injury and systemic inflammation. We find that decreased abundance of Bacteroides uniformis in gut microbiota impairs taurine production and increases IL-17 release in colon that triggers NETs formation. Moreover, Bacteroides uniformis or taurine inhibits the activation of NF-κB and IL-17 signaling pathways in neutrophils which harness NETs and alleviate pancreatic injury. Our findings establish roles of endogenous Bacteroides uniformis-derived metabolic and inflammatory products on suppressing NETs release, which provides potential insights of ameliorating HTGP through gut microbiota modulation.

Suggested Citation

  • Guanqun Li & Liwei Liu & Tianqi Lu & Yuhang Sui & Can Zhang & Yongwei Wang & Tao Zhang & Yu Xie & Peng Xiao & Zhongjie Zhao & Chundong Cheng & Jisheng Hu & Hongze Chen & Dongbo Xue & Hua Chen & Gang W, 2023. "Gut microbiota aggravates neutrophil extracellular traps-induced pancreatic injury in hypertriglyceridemic pancreatitis," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41950-y
    DOI: 10.1038/s41467-023-41950-y
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    References listed on IDEAS

    as
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