Author
Listed:
- Hao Li
(Chinese Academy of Medical Sciences and Peking Union Medical College)
- Haochen Xu
(Chinese Academy of Medical Sciences and Peking Union Medical College)
- Youxiang Li
(Capital Medical University)
- Yuhua Jiang
(Capital Medical University)
- Yamin Hu
(Cangzhou Central Hospital)
- Tingting Liu
(Chinese Academy of Medical Sciences and Peking Union Medical College)
- Xueqing Tian
(Chinese Academy of Medical Sciences and Peking Union Medical College)
- Xihai Zhao
(Tsinghua University)
- Yandong Zhu
(Tsinghua University)
- Shuxia Wang
(Chinese PLA General Hospital and Chinese PLA Medical College)
- Chunrui Zhang
(Novogene Bioinformatics Institute)
- Jing Ge
(Chinese Academy of Medical Sciences and Peking Union Medical College)
- Xuliang Wang
(Chinese Academy of Medical Sciences and Peking Union Medical College)
- Hongyan Wen
(Chinese Academy of Medical Sciences and Peking Union Medical College)
- Congxia Bai
(Chinese Academy of Medical Sciences and Peking Union Medical College)
- Yingying Sun
(Chinese Academy of Medical Sciences and Peking Union Medical College)
- Li Song
(Chinese Academy of Medical Sciences and Peking Union Medical College)
- Yinhui Zhang
(Chinese Academy of Medical Sciences and Peking Union Medical College)
- Rutai Hui
(Chinese Academy of Medical Sciences and Peking Union Medical College)
- Jun Cai
(Chinese Academy of Medical Sciences and Peking Union Medical College)
- Jingzhou Chen
(Chinese Academy of Medical Sciences and Peking Union Medical College)
Abstract
Unruptured intracranial aneurysm (UIA) is a life-threatening cerebrovascular condition. Whether changes in gut microbial composition participate in the development of UIAs remains largely unknown. We perform a case-control metagenome-wide association study in two cohorts of Chinese UIA patients and control individuals and mice that receive fecal transplants from human donors. After fecal transplantation, the UIA microbiota is sufficient to induce UIAs in mice. We identify UIA-associated gut microbial species link to changes in circulating taurine. Specifically, the abundance of Hungatella hathewayi is markedly decreased and positively correlated with the circulating taurine concentration in both humans and mice. Consistently, gavage with H. hathewayi normalizes the taurine levels in serum and protects mice against the formation and rupture of intracranial aneurysms. Taurine supplementation also reverses the progression of intracranial aneurysms. Our findings provide insights into a potential role of H. hathewayi-associated taurine depletion as a key factor in the pathogenesis of UIAs.
Suggested Citation
Hao Li & Haochen Xu & Youxiang Li & Yuhua Jiang & Yamin Hu & Tingting Liu & Xueqing Tian & Xihai Zhao & Yandong Zhu & Shuxia Wang & Chunrui Zhang & Jing Ge & Xuliang Wang & Hongyan Wen & Congxia Bai &, 2020.
"Alterations of gut microbiota contribute to the progression of unruptured intracranial aneurysms,"
Nature Communications, Nature, vol. 11(1), pages 1-15, December.
Handle:
RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16990-3
DOI: 10.1038/s41467-020-16990-3
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