PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer models
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DOI: 10.1038/s41467-023-41737-1
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- Hiroshi Iwata & Claudia Goettsch & Amitabh Sharma & Piero Ricchiuto & Wilson Wen Bin Goh & Arda Halu & Iwao Yamada & Hideo Yoshida & Takuya Hara & Mei Wei & Noriyuki Inoue & Daiju Fukuda & Alexander M, 2016. "PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation," Nature Communications, Nature, vol. 7(1), pages 1-19, November.
- Sanjeev Mariathasan & Shannon J. Turley & Dorothee Nickles & Alessandra Castiglioni & Kobe Yuen & Yulei Wang & Edward E. Kadel III & Hartmut Koeppen & Jillian L. Astarita & Rafael Cubas & Suchit Jhunj, 2018. "TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells," Nature, Nature, vol. 554(7693), pages 544-548, February.
- Su Yin Lim & Elena Shklovskaya & Jenny H. Lee & Bernadette Pedersen & Ashleigh Stewart & Zizhen Ming & Mal Irvine & Brindha Shivalingam & Robyn P. M. Saw & Alexander M. Menzies & Matteo S. Carlino & R, 2023. "The molecular and functional landscape of resistance to immune checkpoint blockade in melanoma," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
- Valeria Iansante & Pui Man Choy & Sze Wai Fung & Ying Liu & Jian-Guo Chai & Julian Dyson & Alberto Del Rio & Clive D’Santos & Roger Williams & Shilpa Chokshi & Robert A Anders & Concetta Bubici & Salv, 2015. "PARP14 promotes the Warburg effect in hepatocellular carcinoma by inhibiting JNK1-dependent PKM2 phosphorylation and activation," Nature Communications, Nature, vol. 6(1), pages 1-15, November.
- Vijay Shankaran & Hiroaki Ikeda & Allen T. Bruce & J. Michael White & Paul E. Swanson & Lloyd J. Old & Robert D. Schreiber, 2001. "IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity," Nature, Nature, vol. 410(6832), pages 1107-1111, April.
- Ling-Wen Ding & Qiao-Yang Sun & Jarem J. Edwards & Lucia Torres Fernández & Xue-Bin Ran & Si-Qin Zhou & Richard A. Scolyer & James S. Wilmott & John F. Thompson & Ngan Doan & Jonathan W. Said & Nachiy, 2019. "LNK suppresses interferon signaling in melanoma," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
- M. Raza Zaidi & Sean Davis & Frances P. Noonan & Cari Graff-Cherry & Teresa S. Hawley & Robert L. Walker & Lionel Feigenbaum & Elaine Fuchs & Lyudmila Lyakh & Howard A. Young & Thomas J. Hornyak & Hei, 2011. "Interferon-γ links ultraviolet radiation to melanomagenesis in mice," Nature, Nature, vol. 469(7331), pages 548-553, January.
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