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Interferon-γ links ultraviolet radiation to melanomagenesis in mice

Author

Listed:
  • M. Raza Zaidi

    (Laboratory of Cancer Biology and Genetics, National Cancer Institute)

  • Sean Davis

    (Genetics Branch, National Cancer Institute)

  • Frances P. Noonan

    (Laboratory of Photobiology and Photoimmunology, Immunology and Tropical Medicine, George Washington University Medical Center)

  • Cari Graff-Cherry

    (Laboratory Animal Sciences Program, National Cancer Institute)

  • Teresa S. Hawley

    (Flow Cytometry Core, George Washington University Medical Center)

  • Robert L. Walker

    (Genetics Branch, National Cancer Institute)

  • Lionel Feigenbaum

    (Laboratory Animal Sciences Program, National Cancer Institute)

  • Elaine Fuchs

    (Rockefeller University)

  • Lyudmila Lyakh

    (Cancer and Inflammation Program, National Cancer Institute)

  • Howard A. Young

    (Cancer and Inflammation Program, National Cancer Institute)

  • Thomas J. Hornyak

    (Dermatology Branch, National Cancer Institute)

  • Heinz Arnheiter

    (National Institute of Neurological Disorders and Stroke)

  • Giorgio Trinchieri

    (Cancer and Inflammation Program, National Cancer Institute)

  • Paul S. Meltzer

    (Genetics Branch, National Cancer Institute)

  • Edward C. De Fabo

    (Laboratory of Photobiology and Photoimmunology, Immunology and Tropical Medicine, George Washington University Medical Center)

  • Glenn Merlino

    (Laboratory of Cancer Biology and Genetics, National Cancer Institute)

Abstract

How UV induces melanoma Exposure to ultraviolet (UV) radiation has been implicated in melanoma formation. Glenn Merlino and colleagues now show, in a mouse model, that UVB irradiation induces the recruitment of macrophages that produce interferon-γ to promote melanoma formation. The study suggests that agents that target interferon-γ may have therapeutic potential in patients with melanoma.

Suggested Citation

  • M. Raza Zaidi & Sean Davis & Frances P. Noonan & Cari Graff-Cherry & Teresa S. Hawley & Robert L. Walker & Lionel Feigenbaum & Elaine Fuchs & Lyudmila Lyakh & Howard A. Young & Thomas J. Hornyak & Hei, 2011. "Interferon-γ links ultraviolet radiation to melanomagenesis in mice," Nature, Nature, vol. 469(7331), pages 548-553, January.
    • Handle: RePEc:nat:nature:v:469:y:2011:i:7331:d:10.1038_nature09666
    DOI: 10.1038/nature09666
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    Cited by:

    1. Luye An & Dahihm Kim & Leanne R. Donahue & Menansili Abraham Mejooli & Chi-Yong Eom & Nozomi Nishimura & Andrew C. White, 2024. "Sexual dimorphism in melanocyte stem cell behavior reveals combinational therapeutic strategies for cutaneous repigmentation," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Chun Wai Wong & Christos Evangelou & Kieran N. Sefton & Rotem Leshem & Wei Zhang & Vishaka Gopalan & Sorayut Chattrakarn & Macarena Lucia Fernandez Carro & Erez Uzuner & Holly Mole & Daniel J. Wilcock, 2023. "PARP14 inhibition restores PD-1 immune checkpoint inhibitor response following IFNγ-driven acquired resistance in preclinical cancer models," Nature Communications, Nature, vol. 14(1), pages 1-21, December.

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