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Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment

Author

Listed:
  • Tra Vinikoor

    (University of Connecticut
    University of Connecticut Health)

  • Godwin K. Dzidotor

    (University of Connecticut Health
    University of Connecticut)

  • Thinh T. Le

    (University of Connecticut)

  • Yang Liu

    (Center of Digital Dentistry/Department of Prosthodontics/Central Laboratory, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices & Beijing Key Laboratory of Digital Stomatology & NHC Research Center of Engineering and Technology for Computerized Dentistry & NMPA Key Laboratory for Dental Materials)

  • Ho-Man Kan

    (University of Connecticut Health)

  • Srimanta Barui

    (University of Connecticut Health)

  • Meysam T. Chorsi

    (University of Connecticut)

  • Eli J. Curry

    (Eli Lilly and Company
    University of Connecticut)

  • Emily Reinhardt

    (University of Connecticut)

  • Hanzhang Wang

    (University of Connecticut Health Center)

  • Parbeen Singh

    (University of Connecticut)

  • Marc A. Merriman

    (University of Connecticut Health
    University of Connecticut)

  • Ethan D’Orio

    (University of Connecticut)

  • Jinyoung Park

    (University of Connecticut)

  • Shuyang Xiao

    (University of Connecticut)

  • James H. Chapman

    (University of Connecticut Health)

  • Feng Lin

    (University of Connecticut)

  • Cao-Sang Truong

    (University of Connecticut)

  • Somasundaram Prasadh

    (University of Connecticut)

  • Lisa Chuba

    (University of Connecticut Health Center)

  • Shaelyn Killoh

    (University of Connecticut Health Center)

  • Seok-Woo Lee

    (University of Connecticut
    University of Connecticut)

  • Qian Wu

    (University of Connecticut Health Center)

  • Ramaswamy M. Chidambaram

    (University of Connecticut Health Center)

  • Kevin W. H. Lo

    (University of Connecticut Health
    University of Connecticut
    University of Connecticut Health Center)

  • Cato T. Laurencin

    (University of Connecticut
    University of Connecticut Health
    University of Connecticut
    University of Connecticut)

  • Thanh D. Nguyen

    (University of Connecticut
    University of Connecticut
    University of Connecticut)

Abstract

Osteoarthritis affects millions of people worldwide but current treatments using analgesics or anti-inflammatory drugs only alleviate symptoms of this disease. Here, we present an injectable, biodegradable piezoelectric hydrogel, made of short electrospun poly-L-lactic acid nanofibers embedded inside a collagen matrix, which can be injected into the joints and self-produce localized electrical cues under ultrasound activation to drive cartilage healing. In vitro, data shows that the piezoelectric hydrogel with ultrasound can enhance cell migration and induce stem cells to secrete TGF-β1, which promotes chondrogenesis. In vivo, the rabbits with osteochondral critical-size defects receiving the ultrasound-activated piezoelectric hydrogel show increased subchondral bone formation, improved hyaline-cartilage structure, and good mechanical properties, close to healthy native cartilage. This piezoelectric hydrogel is not only useful for cartilage healing but also potentially applicable to other tissue regeneration, offering a significant impact on the field of regenerative tissue engineering.

Suggested Citation

  • Tra Vinikoor & Godwin K. Dzidotor & Thinh T. Le & Yang Liu & Ho-Man Kan & Srimanta Barui & Meysam T. Chorsi & Eli J. Curry & Emily Reinhardt & Hanzhang Wang & Parbeen Singh & Marc A. Merriman & Ethan , 2023. "Injectable and biodegradable piezoelectric hydrogel for osteoarthritis treatment," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41594-y
    DOI: 10.1038/s41467-023-41594-y
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    References listed on IDEAS

    as
    1. Canan Dagdeviren & Yewang Su & Pauline Joe & Raissa Yona & Yuhao Liu & Yun-Soung Kim & YongAn Huang & Anoop R. Damadoran & Jing Xia & Lane W. Martin & Yonggang Huang & John A. Rogers, 2014. "Conformable amplified lead zirconate titanate sensors with enhanced piezoelectric response for cutaneous pressure monitoring," Nature Communications, Nature, vol. 5(1), pages 1-10, December.
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    Cited by:

    1. Zhouquan Sun & Yuefan Jin & Jiabei Luo & Linpeng Li & Yue Ding & Yu Luo & Yan Qi & Yaogang Li & Qinghong Zhang & Kerui Li & Haibo Shi & Shankai Yin & Hongzhi Wang & Hui Wang & Chengyi Hou, 2024. "A bioabsorbable mechanoelectric fiber as electrical stimulation suture," Nature Communications, Nature, vol. 15(1), pages 1-12, December.

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