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A Glycolipidated-liposomal peptide vaccine confers long-term mucosal protection against Streptococcus pyogenes via IL-17, macrophages and neutrophils

Author

Listed:
  • Victoria Ozberk

    (Griffith University)

  • Mehfuz Zaman

    (Griffith University)

  • Ailin Lepletier

    (Griffith University)

  • Sharareh Eskandari

    (Griffith University)

  • Jacqualine Kaden

    (Griffith University)

  • Jamie-Lee Mills

    (Griffith University)

  • Ainslie Calcutt

    (Griffith University)

  • Jessica Dooley

    (Griffith University)

  • Yongbao Huo

    (Griffith University)

  • Emma L. Langshaw

    (Griffith University)

  • Glen C. Ulett

    (Griffith University)

  • Michael R. Batzloff

    (Griffith University)

  • Michael F. Good

    (Griffith University)

  • Manisha Pandey

    (Griffith University)

Abstract

Mucosally active subunit vaccines are an unmet clinical need due to lack of licensed immunostimulants suitable for vaccine antigens. Here, we show that intranasal administration of liposomes incorporating: the Streptococcus pyogenes peptide antigen, J8; diphtheria toxoid as a source of T cell help; and the immunostimulatory glycolipid, 3D(6-acyl) PHAD (PHAD), is able to induce long-lived humoral and cellular immunity. Mice genetically deficient in either mucosal antibodies or total antibodies are protected against S. pyogenes respiratory tract infection. Utilizing IL-17-deficient mice or depleting cellular subsets using antibodies, shows that the cellular responses encompassing, CD4+ T cells, IL-17, macrophages and neutrophils have important functions in vaccine-mediated mucosal immunity. Overall, these data demonstrate the utility of a mucosal vaccine platform to deliver multi-pronged protective responses against a highly virulent pathogen.

Suggested Citation

  • Victoria Ozberk & Mehfuz Zaman & Ailin Lepletier & Sharareh Eskandari & Jacqualine Kaden & Jamie-Lee Mills & Ainslie Calcutt & Jessica Dooley & Yongbao Huo & Emma L. Langshaw & Glen C. Ulett & Michael, 2023. "A Glycolipidated-liposomal peptide vaccine confers long-term mucosal protection against Streptococcus pyogenes via IL-17, macrophages and neutrophils," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41410-7
    DOI: 10.1038/s41467-023-41410-7
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    References listed on IDEAS

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    1. Nathalie Percie du Sert & Viki Hurst & Amrita Ahluwalia & Sabina Alam & Marc T Avey & Monya Baker & William J Browne & Alejandra Clark & Innes C Cuthill & Ulrich Dirnagl & Michael Emerson & Paul Garne, 2020. "The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research," PLOS Biology, Public Library of Science, vol. 18(7), pages 1-12, July.
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    1. Nick Huang & Thomas Winans & Brandon Wyman & Zachary Oaks & Tamas Faludi & Gourav Choudhary & Zhi-Wei Lai & Joshua Lewis & Miguel Beckford & Manuel Duarte & Daniel Krakko & Akshay Patel & Joy Park & T, 2024. "Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation," Nature Communications, Nature, vol. 15(1), pages 1-26, December.

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