Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR
Author
Abstract
Suggested Citation
DOI: 10.1038/s41467-023-41199-5
Download full text from publisher
References listed on IDEAS
- Shoji Maeda & Antoine Koehl & Hugues Matile & Hongli Hu & Daniel Hilger & Gebhard F. X. Schertler & Aashish Manglik & Georgios Skiniotis & Roger J. P. Dawson & Brian K. Kobilka, 2018. "Development of an antibody fragment that stabilizes GPCR/G-protein complexes," Nature Communications, Nature, vol. 9(1), pages 1-9, December.
- Kazuko Haga & Andrew C. Kruse & Hidetsugu Asada & Takami Yurugi-Kobayashi & Mitsunori Shiroishi & Cheng Zhang & William I. Weis & Tetsuji Okada & Brian K. Kobilka & Tatsuya Haga & Takuya Kobayashi, 2012. "Structure of the human M2 muscarinic acetylcholine receptor bound to an antagonist," Nature, Nature, vol. 482(7386), pages 547-551, February.
- Sukanta Saha & David Chant & Joy Welham & John McGrath, 2005. "A Systematic Review of the Prevalence of Schizophrenia," PLOS Medicine, Public Library of Science, vol. 2(5), pages 1-1, May.
- Jingjing Wang & Meng Wu & Zhangcheng Chen & Lijie Wu & Tian Wang & Dongmei Cao & Huan Wang & Shenhui Liu & Yueming Xu & Fei Li & Junlin Liu & Na Chen & Suwen Zhao & Jianjun Cheng & Sheng Wang & Tian H, 2022. "The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
- Andrew C. Kruse & Aaron M. Ring & Aashish Manglik & Jianxin Hu & Kelly Hu & Katrin Eitel & Harald Hübner & Els Pardon & Celine Valant & Patrick M. Sexton & Arthur Christopoulos & Christian C. Felder &, 2013. "Activation and allosteric modulation of a muscarinic acetylcholine receptor," Nature, Nature, vol. 504(7478), pages 101-106, December.
- David M. Thal & Bingfa Sun & Dan Feng & Vindhya Nawaratne & Katie Leach & Christian C. Felder & Mark G. Bures & David A. Evans & William I. Weis & Priti Bachhawat & Tong Sun Kobilka & Patrick M. Sexto, 2016. "Crystal structures of the M1 and M4 muscarinic acetylcholine receptors," Nature, Nature, vol. 531(7594), pages 335-340, March.
- Fan Yang & Chunyou Mao & Lulu Guo & Jingyu Lin & Qianqian Ming & Peng Xiao & Xiang Wu & Qingya Shen & Shimeng Guo & Dan-Dan Shen & Ruirui Lu & Linqi Zhang & Shenming Huang & Yuqi Ping & Chenlu Zhang &, 2020. "Structural basis of GPBAR activation and bile acid recognition," Nature, Nature, vol. 587(7834), pages 499-504, November.
- Andrew C. Kruse & Jianxin Hu & Albert C. Pan & Daniel H. Arlow & Daniel M. Rosenbaum & Erica Rosemond & Hillary F. Green & Tong Liu & Pil Seok Chae & Ron O. Dror & David E. Shaw & William I. Weis & Jü, 2012. "Structure and dynamics of the M3 muscarinic acetylcholine receptor," Nature, Nature, vol. 482(7386), pages 552-556, February.
- Shicheng Zhang & Ryan H. Gumpper & Xi-Ping Huang & Yongfeng Liu & Brian E. Krumm & Can Cao & Jonathan F. Fay & Bryan L. Roth, 2022. "Molecular basis for selective activation of DREADD-based chemogenetics," Nature, Nature, vol. 612(7939), pages 354-362, December.
Most related items
These are the items that most often cite the same works as this one and are cited by the same works as this one.- Jun Xu & Qinggong Wang & Harald Hübner & Yunfei Hu & Xiaogang Niu & Haoqing Wang & Shoji Maeda & Asuka Inoue & Yuyong Tao & Peter Gmeiner & Yang Du & Changwen Jin & Brian K. Kobilka, 2023. "Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
- Geng Chen & Jun Xu & Asuka Inoue & Maximilian F. Schmidt & Chen Bai & Qiuyuan Lu & Peter Gmeiner & Zheng Liu & Yang Du, 2022. "Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
- Yang Yang & Hye Jin Kang & Ruogu Gao & Jingjing Wang & Gye Won Han & Jeffrey F. DiBerto & Lijie Wu & Jiahui Tong & Lu Qu & Yiran Wu & Ryan Pileski & Xuemei Li & Xuejun Cai Zhang & Suwen Zhao & Terry K, 2023. "Structural insights into the human niacin receptor HCA2-Gi signalling complex," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
- Joshua A. Lees & João M. Dias & Francis Rajamohan & Jean-Philippe Fortin & Rebecca O’Connor & Jimmy X. Kong & Emily A. G. Hughes & Ethan L. Fisher & Jamison B. Tuttle & Gabrielle Lovett & Bethany L. K, 2023. "An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
- Hongmin Cai & Shimeng Guo & Youwei Xu & Jun Sun & Junrui Li & Zhikan Xia & Yi Jiang & Xin Xie & H. Eric Xu, 2024. "Cryo-EM structures of adenosine receptor A3AR bound to selective agonists," Nature Communications, Nature, vol. 15(1), pages 1-10, December.
- Xuan Zhang & Yujing Wang & Shreyas Supekar & Xu Cao & Jingkai Zhou & Jessica Dang & Siqi Chen & Laura Jenkins & Sara Marsango & Xiu Li & Guibing Liu & Graeme Milligan & Mingye Feng & Hao Fan & Weimin , 2023. "Pro-phagocytic function and structural basis of GPR84 signaling," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
- Ling Wang & Xi-Wang Fan & Xu-Dong Zhao & Bing-Gen Zhu & Hong-Yun Qin, 2020. "Correlation Analysis of the Quality of Family Functioning and Subjective Quality of Life in Rehabilitation Patients Living with Schizophrenia in the Community," IJERPH, MDPI, vol. 17(7), pages 1-9, April.
- Jia Duan & Dan-Dan Shen & Tingting Zhao & Shimeng Guo & Xinheng He & Wanchao Yin & Peiyu Xu & Yujie Ji & Li-Nan Chen & Jinyu Liu & Huibing Zhang & Qiufeng Liu & Yi Shi & Xi Cheng & Hualiang Jiang & H., 2022. "Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
- Noriyuki Uchida & Ai Kohata & Kou Okuro & Annalisa Cardellini & Chiara Lionello & Eric A. Zizzi & Marco A. Deriu & Giovanni M. Pavan & Michio Tomishige & Takaaki Hikima & Takuzo Aida, 2022. "Reconstitution of microtubule into GTP-responsive nanocapsules," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
- Yann Waltenspühl & Janosch Ehrenmann & Santiago Vacca & Cristian Thom & Ohad Medalia & Andreas Plückthun, 2022. "Structural basis for the activation and ligand recognition of the human oxytocin receptor," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
- Xueqian Peng & Linlin Yang & Zixuan Liu & Siyi Lou & Shiliu Mei & Meiling Li & Zhong Chen & Haitao Zhang, 2022. "Structural basis for recognition of antihistamine drug by human histamine receptor," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
- Huichen Gao & Shijuan Wang, 2022. "The Intellectual Structure of Research on Rural-to-Urban Migrants: A Bibliometric Analysis," IJERPH, MDPI, vol. 19(15), pages 1-19, August.
- Na Wang & Xinheng He & Jing Zhao & Hualiang Jiang & Xi Cheng & Yu Xia & H. Eric Xu & Yuanzheng He, 2022. "Structural basis of leukotriene B4 receptor 1 activation," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
- Liu Liu & Kimberley El & Diptadip Dattaroy & Luiz F. Barella & Yinghong Cui & Sarah M. Gray & Carla Guedikian & Min Chen & Lee S. Weinstein & Emily Knuth & Erli Jin & Matthew J. Merrins & Jeffrey Roma, 2024. "Intra-islet α-cell Gs signaling promotes glucagon release," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
- Ó Gráda, Cormac & Lee, Chihua & Lumey, L. H., 2023. "How Much Schizophrenia Do Famines Cause?," MPRA Paper 119448, University Library of Munich, Germany.
- Canrong Wu & Youwei Xu & Qian He & Dianrong Li & Jia Duan & Changyao Li & Chongzhao You & Han Chen & Weiliang Fan & Yi Jiang & H. Eric Xu, 2023. "Ligand-induced activation and G protein coupling of prostaglandin F2α receptor," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
- Geng Chen & Xiankun Wang & Qiwen Liao & Yunjun Ge & Haizhan Jiao & Qiang Chen & Yezhou Liu & Wenping Lyu & Lizhe Zhu & Gydo C. P. Zundert & Michael J. Robertson & Georgios Skiniotis & Yang Du & Hongli, 2022. "Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns," Nature Communications, Nature, vol. 13(1), pages 1-13, December.
- Nathan T. Pearson & James H. Berry, 2019. "Cannabis and Psychosis Through the Lens of DSM-5," IJERPH, MDPI, vol. 16(21), pages 1-14, October.
- Ary Gadelha & Vanessa Kiyomi Ota & Jose Paya Cano & Maria Isabel Melaragno & Marilia A C Smith & Jair de Jesus Mari & Rodrigo A Bressan & Sintia Iole Belangero & Gerome Breen, 2012. "Linkage Replication for Chromosomal Region 13q32 in Schizophrenia: Evidence from a Brazilian Pilot Study on Early Onset Schizophrenia Families," PLOS ONE, Public Library of Science, vol. 7(12), pages 1-6, December.
- Song, Shige & Wang, Wei & Hu, Peifeng, 2009. "Famine, death, and madness: Schizophrenia in early adulthood after prenatal exposure to the Chinese Great Leap Forward Famine," Social Science & Medicine, Elsevier, vol. 68(7), pages 1315-1321, April.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41199-5. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through the various RePEc services.