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Comprehensive proteomics and meta-analysis of COVID-19 host response

Author

Listed:
  • Haris Babačić

    (Karolinska Institutet)

  • Wanda Christ

    (Karolinska Institutet)

  • José Eduardo Araújo

    (Karolinska Institutet)

  • Georgios Mermelekas

    (Karolinska Institutet)

  • Nidhi Sharma

    (Karolinska Institutet)

  • Janne Tynell

    (Karolinska Institutet)

  • Marina García

    (Karolinska Institutet)

  • Renata Varnaite

    (Karolinska Institutet)

  • Hilmir Asgeirsson

    (Karolinska University Hospital
    Karolinska Institutet)

  • Hedvig Glans

    (Karolinska Institutet
    Karolinska University Hospital)

  • Janne Lehtiö

    (Karolinska Institutet)

  • Sara Gredmark-Russ

    (Karolinska Institutet
    Karolinska University Hospital
    The Laboratory for Molecular Infection Medicine Sweden (MIMS))

  • Jonas Klingström

    (Karolinska Institutet
    Linköping University)

  • Maria Pernemalm

    (Karolinska Institutet)

Abstract

COVID-19 is characterised by systemic immunological perturbations in the human body, which can lead to multi-organ damage. Many of these processes are considered to be mediated by the blood. Therefore, to better understand the systemic host response to SARS-CoV-2 infection, we performed systematic analyses of the circulating, soluble proteins in the blood through global proteomics by mass-spectrometry (MS) proteomics. Here, we show that a large part of the soluble blood proteome is altered in COVID-19, among them elevated levels of interferon-induced and proteasomal proteins. Some proteins that have alternating levels in human cells after a SARS-CoV-2 infection in vitro and in different organs of COVID-19 patients are deregulated in the blood, suggesting shared infection-related changes.The availability of different public proteomic resources on soluble blood proteome alterations leaves uncertainty about the change of a given protein during COVID-19. Hence, we performed a systematic review and meta-analysis of MS global proteomics studies of soluble blood proteomes, including up to 1706 individuals (1039 COVID-19 patients), to provide concluding estimates for the alteration of 1517 soluble blood proteins in COVID-19. Finally, based on the meta-analysis we developed CoViMAPP, an open-access resource for effect sizes of alterations and diagnostic potential of soluble blood proteins in COVID-19, which is publicly available for the research, clinical, and academic community.

Suggested Citation

  • Haris Babačić & Wanda Christ & José Eduardo Araújo & Georgios Mermelekas & Nidhi Sharma & Janne Tynell & Marina García & Renata Varnaite & Hilmir Asgeirsson & Hedvig Glans & Janne Lehtiö & Sara Gredma, 2023. "Comprehensive proteomics and meta-analysis of COVID-19 host response," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41159-z
    DOI: 10.1038/s41467-023-41159-z
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    References listed on IDEAS

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