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Divergent sequences of tetraspanins enable plants to specifically recognize microbe-derived extracellular vesicles

Author

Listed:
  • Jinyi Zhu

    (Nanjing Agricultural University)

  • Qian Qiao

    (Nanjing Agricultural University)

  • Yujing Sun

    (Nanjing Agricultural University)

  • Yuanpeng Xu

    (Nanjing Agricultural University)

  • Haidong Shu

    (Nanjing Agricultural University)

  • Zhichao Zhang

    (Nanjing Agricultural University)

  • Fan Liu

    (Nanjing Agricultural University)

  • Haonan Wang

    (Nanjing Agricultural University)

  • Wenwu Ye

    (Nanjing Agricultural University
    The Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education)
    Nanjing Agricultural University)

  • Suomeng Dong

    (Nanjing Agricultural University
    The Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education)
    Nanjing Agricultural University)

  • Yan Wang

    (Nanjing Agricultural University
    The Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education)
    Nanjing Agricultural University)

  • Zhenchuan Ma

    (Nanjing Agricultural University
    The Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education)
    Nanjing Agricultural University)

  • Yuanchao Wang

    (Nanjing Agricultural University
    The Key Laboratory of Integrated Management of Crop Diseases and Pests (Ministry of Education)
    Nanjing Agricultural University)

Abstract

Extracellular vesicles (EVs) are important for cell-to-cell communication in animals. EVs also play important roles in plant–microbe interactions, but the underlying mechanisms remain elusive. Here, proteomic analyses of EVs from the soybean (Glycine max) root rot pathogen Phytophthora sojae identify the tetraspanin family proteins PsTET1 and PsTET3, which are recognized by Nicotiana benthamiana to trigger plant immune responses. Both proteins are required for the full virulence of P. sojae. The large extracellular loop (EC2) of PsTET3 is the key region recognized by N. benthamiana and soybean cells in a plant receptor-like kinase NbSERK3a/b dependent manner. TET proteins from oomycete and fungal plant pathogens are recognized by N. benthamiana thus inducing immune responses, whereas plant-derived TET proteins are not due to the sequence divergence of sixteen amino acids at the C-terminal of EC2. This feature allows plants to distinguish self and non-self EVs to trigger active defense responses against pathogenic eukaryotes.

Suggested Citation

  • Jinyi Zhu & Qian Qiao & Yujing Sun & Yuanpeng Xu & Haidong Shu & Zhichao Zhang & Fan Liu & Haonan Wang & Wenwu Ye & Suomeng Dong & Yan Wang & Zhenchuan Ma & Yuanchao Wang, 2023. "Divergent sequences of tetraspanins enable plants to specifically recognize microbe-derived extracellular vesicles," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-40623-0
    DOI: 10.1038/s41467-023-40623-0
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    References listed on IDEAS

    as
    1. Yan Wang & Yuanpeng Xu & Yujing Sun & Huibin Wang & Jiaming Qi & Bowen Wan & Wenwu Ye & Yachun Lin & Yuanyuan Shao & Suomeng Dong & Brett M. Tyler & Yuanchao Wang, 2018. "Leucine-rich repeat receptor-like gene screen reveals that Nicotiana RXEG1 regulates glycoside hydrolase 12 MAMP detection," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    2. Rie Umeda & Yuhkoh Satouh & Mizuki Takemoto & Yoshiko Nakada-Nakura & Kehong Liu & Takeshi Yokoyama & Mikako Shirouzu & So Iwata & Norimichi Nomura & Ken Sato & Masahito Ikawa & Tomohiro Nishizawa & O, 2020. "Structural insights into tetraspanin CD9 function," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
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