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Human orbitofrontal cortex signals decision outcomes to sensory cortex during behavioral adaptations

Author

Listed:
  • Bin A. Wang

    (Ruhr-University Bochum
    Ruhr-University Bochum)

  • Maike Veismann

    (Ruhr-University Bochum
    Ruhr-University Bochum)

  • Abhishek Banerjee

    (Newcastle University)

  • Burkhard Pleger

    (Ruhr-University Bochum
    Ruhr-University Bochum)

Abstract

The ability to respond flexibly to an ever-changing environment relies on the orbitofrontal cortex (OFC). However, how the OFC associates sensory information with predicted outcomes to enable flexible sensory learning in humans remains elusive. Here, we combine a probabilistic tactile reversal learning task with functional magnetic resonance imaging (fMRI) to investigate how lateral OFC (lOFC) interacts with the primary somatosensory cortex (S1) to guide flexible tactile learning in humans. fMRI results reveal that lOFC and S1 exhibit distinct task-dependent engagement: while the lOFC responds transiently to unexpected outcomes immediately following reversals, S1 is persistently engaged during re-learning. Unlike the contralateral stimulus-selective S1, activity in ipsilateral S1 mirrors the outcomes of behavior during re-learning, closely related to top-down signals from lOFC. These findings suggest that lOFC contributes to teaching signals to dynamically update representations in sensory areas, which implement computations critical for adaptive behavior.

Suggested Citation

  • Bin A. Wang & Maike Veismann & Abhishek Banerjee & Burkhard Pleger, 2023. "Human orbitofrontal cortex signals decision outcomes to sensory cortex during behavioral adaptations," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38671-7
    DOI: 10.1038/s41467-023-38671-7
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    References listed on IDEAS

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    1. Dechen Liu & Juan Deng & Zhewei Zhang & Zhi-Yu Zhang & Yan-Gang Sun & Tianming Yang & Haishan Yao, 2020. "Orbitofrontal control of visual cortex gain promotes visual associative learning," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    2. Abhishek Banerjee & Giuseppe Parente & Jasper Teutsch & Christopher Lewis & Fabian F. Voigt & Fritjof Helmchen, 2020. "Value-guided remapping of sensory cortex by lateral orbitofrontal cortex," Nature, Nature, vol. 585(7824), pages 245-250, September.
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