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Orbitofrontal control of visual cortex gain promotes visual associative learning

Author

Listed:
  • Dechen Liu

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Juan Deng

    (Chinese Academy of Sciences)

  • Zhewei Zhang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences
    Chinese Academy of Sciences)

  • Zhi-Yu Zhang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yan-Gang Sun

    (Chinese Academy of Sciences
    Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology)

  • Tianming Yang

    (Chinese Academy of Sciences
    Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology)

  • Haishan Yao

    (Chinese Academy of Sciences
    Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology)

Abstract

The orbitofrontal cortex (OFC) encodes expected outcomes and plays a critical role in flexible, outcome-guided behavior. The OFC projects to primary visual cortex (V1), yet the function of this top-down projection is unclear. We find that optogenetic activation of OFC projection to V1 reduces the amplitude of V1 visual responses via the recruitment of local somatostatin-expressing (SST) interneurons. Using mice performing a Go/No-Go visual task, we show that the OFC projection to V1 mediates the outcome-expectancy modulation of V1 responses to the reward-irrelevant No-Go stimulus. Furthermore, V1-projecting OFC neurons reduce firing during expectation of reward. In addition, chronic optogenetic inactivation of OFC projection to V1 impairs, whereas chronic activation of SST interneurons in V1 improves the learning of Go/No-Go visual task, without affecting the immediate performance. Thus, OFC top-down projection to V1 is crucial to drive visual associative learning by modulating the response gain of V1 neurons to non-relevant stimulus.

Suggested Citation

  • Dechen Liu & Juan Deng & Zhewei Zhang & Zhi-Yu Zhang & Yan-Gang Sun & Tianming Yang & Haishan Yao, 2020. "Orbitofrontal control of visual cortex gain promotes visual associative learning," Nature Communications, Nature, vol. 11(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:11:y:2020:i:1:d:10.1038_s41467-020-16609-7
    DOI: 10.1038/s41467-020-16609-7
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    Cited by:

    1. Bin A. Wang & Maike Veismann & Abhishek Banerjee & Burkhard Pleger, 2023. "Human orbitofrontal cortex signals decision outcomes to sensory cortex during behavioral adaptations," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Qi Wang & Jia-Jie Zhu & Lizhao Wang & Yan-Peng Kan & Yan-Mei Liu & Yan-Jiao Wu & Xue Gu & Xin Yi & Ze-Jie Lin & Qin Wang & Jian-Fei Lu & Qin Jiang & Ying Li & Ming-Gang Liu & Nan-Jie Xu & Michael X. Z, 2022. "Insular cortical circuits as an executive gateway to decipher threat or extinction memory via distinct subcortical pathways," Nature Communications, Nature, vol. 13(1), pages 1-17, December.

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