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Single-cell analysis of gastric signet ring cell carcinoma reveals cytological and immune microenvironment features

Author

Listed:
  • Weizhu Zhao

    (Shandong University Cancer Center
    Shandong First Medical University and Shandong Academy of Medical Sciences
    Binzhou People’s Hospital Affiliated to Shandong First Medical University)

  • Yanfei Jia

    (Shandong First Medical University)

  • Guangyu Sun

    (Binzhou People’s Hospital Affiliated to Shandong First Medical University)

  • Haiying Yang

    (Binzhou People’s Hospital Affiliated to Shandong First Medical University)

  • Luguang Liu

    (Shandong First Medical University and Shandong Academy of Medical Sciences)

  • Xianlin Qu

    (Shandong First Medical University and Shandong Academy of Medical Sciences)

  • Jishuang Ding

    (Shandong First Medical University and Shandong Academy of Medical Sciences)

  • Hang Yu

    (Shandong First Medical University and Shandong Academy of Medical Sciences)

  • Botao Xu

    (Shandong First Medical University and Shandong Academy of Medical Sciences)

  • Siwei Zhao

    (Shandong First Medical University and Shandong Academy of Medical Sciences)

  • Ligang Xing

    (Shandong University Cancer Center
    Shandong First Medical University and Shandong Academy of Medical Sciences)

  • Jie Chai

    (Shandong First Medical University and Shandong Academy of Medical Sciences)

Abstract

Gastric signet ring cell carcinoma (GSRC) is a special subtype of gastric cancer (GC) associated with poor prognosis, but an in-depth and systematic study of GSRC is lacking. Here, we perform single-cell RNA sequencing to assess GC samples. We identify signet ring cell carcinoma (SRCC) cells. Microseminoprotein-beta (MSMB) can be used as a marker gene to guide the identification of moderately/poorly differentiated adenocarcinoma and signet ring cell carcinoma (SRCC). The upregulated differentially expressed genes in SRCC cells are mainly enriched in abnormally activated cancer-related signalling pathways and immune response signalling pathways. SRCC cells are also significantly enriched in mitogen-activated protein kinase and oestrogen signalling pathways, which can interact and promote each other in a positive feedback loop. SRCC cells are shown to have lower cell adhesion and higher immune evasion capabilities as well as an immunosuppressive microenvironment, which may be closely associated with the relatively poor prognosis of GSRC. In summary, GSRC exhibits unique cytological characteristics and a unique immune microenvironment, which may be advantageous for accurate diagnosis and treatment.

Suggested Citation

  • Weizhu Zhao & Yanfei Jia & Guangyu Sun & Haiying Yang & Luguang Liu & Xianlin Qu & Jishuang Ding & Hang Yu & Botao Xu & Siwei Zhao & Ligang Xing & Jie Chai, 2023. "Single-cell analysis of gastric signet ring cell carcinoma reveals cytological and immune microenvironment features," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-38426-4
    DOI: 10.1038/s41467-023-38426-4
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    References listed on IDEAS

    as
    1. Xiaowen Liu & Hong Cai & Weiqi Sheng & Lin Yu & Ziwen Long & Yingqiang Shi & Yanong Wang, 2015. "Clinicopathological Characteristics and Survival Outcomes of Primary Signet Ring Cell Carcinoma in the Stomach: Retrospective Analysis of Single Center Database," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-13, December.
    2. Hiroyuki Tezuka & Yukiko Abe & Makoto Iwata & Hajime Takeuchi & Hiromichi Ishikawa & Masayuki Matsushita & Tetsuo Shiohara & Shizuo Akira & Toshiaki Ohteki, 2007. "Regulation of IgA production by naturally occurring TNF/iNOS-producing dendritic cells," Nature, Nature, vol. 448(7156), pages 929-933, August.
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