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Clinicopathological Characteristics and Survival Outcomes of Primary Signet Ring Cell Carcinoma in the Stomach: Retrospective Analysis of Single Center Database

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  • Xiaowen Liu
  • Hong Cai
  • Weiqi Sheng
  • Lin Yu
  • Ziwen Long
  • Yingqiang Shi
  • Yanong Wang

Abstract

Purpose: To investigate the clinicopathological features and prognosis of signet ring cell carcinoma of the stomach (SRC). Methods: A total of 1464 gastric cancer patients who underwent curative gastrectomy from 2000 to 2008 at a single center were evaluated. Signet ring cell carcinoma (SRC) was defined as the presence of at least 50% signet ring cells in the pathologic specimen. The clinicopathological parameters and prognosis of SRC were analyzed by comparing with non-signet ring cell carcinoma (NSRC). Results: Of 1464 patients, 138 patients (9.4%) were classified as SRC. There were significant differences in gender, age, tumor location, TNM stage, p21 expression, and p53 expression between SRC and NSRC. The 5-year survival rates of SRC and NSRC were 36.2% and 49.5%, respectively. The prognosis of SRC was poorer than that of NSRC (P

Suggested Citation

  • Xiaowen Liu & Hong Cai & Weiqi Sheng & Lin Yu & Ziwen Long & Yingqiang Shi & Yanong Wang, 2015. "Clinicopathological Characteristics and Survival Outcomes of Primary Signet Ring Cell Carcinoma in the Stomach: Retrospective Analysis of Single Center Database," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0144420
    DOI: 10.1371/journal.pone.0144420
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    Cited by:

    1. Weizhu Zhao & Yanfei Jia & Guangyu Sun & Haiying Yang & Luguang Liu & Xianlin Qu & Jishuang Ding & Hang Yu & Botao Xu & Siwei Zhao & Ligang Xing & Jie Chai, 2023. "Single-cell analysis of gastric signet ring cell carcinoma reveals cytological and immune microenvironment features," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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