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Associations between mental health, blood pressure and the development of hypertension

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  • H. Lina Schaare

    (Max Planck Institute for Human Cognitive and Brain Sciences
    Otto-Hahn-Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences
    Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich
    Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf)

  • Maria Blöchl

    (Max Planck Institute for Human Cognitive and Brain Sciences
    Institute for Psychology, Leipzig University)

  • Deniz Kumral

    (Max Planck Institute for Human Cognitive and Brain Sciences
    Institute of Psychology, Neuropsychology, University of Freiburg
    Institute of Psychology, Clinical Psychology and Psychotherapy Unit, University of Freiburg)

  • Marie Uhlig

    (Max Planck Institute for Human Cognitive and Brain Sciences)

  • Lorenz Lemcke

    (Nuclear Magnetic Resonance Unit, Max Planck Institute for Human Cognitive and Brain Sciences)

  • Sofie L. Valk

    (Otto-Hahn-Group Cognitive Neurogenetics, Max Planck Institute for Human Cognitive and Brain Sciences
    Institute of Neuroscience and Medicine (INM-7: Brain and Behaviour), Research Centre Jülich
    Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf)

  • Arno Villringer

    (Max Planck Institute for Human Cognitive and Brain Sciences
    MindBrainBody Institute, Berlin School of Mind and Brain
    Clinic of Cognitive Neurology, Leipzig University
    Charité University Medicine Berlin)

Abstract

Multiple studies have reported a link between mental health and high blood pressure with mixed or even contradictory findings. Here, we resolve those contradictions and further dissect the cross-sectional and longitudinal relationship between mental health, systolic blood pressure, and hypertension using extensive psychological, medical and neuroimaging data from the UK Biobank. We show that higher systolic blood pressure is associated with fewer depressive symptoms, greater well-being, and lower emotion-related brain activity. Interestingly, impending hypertension is associated with poorer mental health years before HTN is diagnosed. In addition, a stronger baseline association between systolic blood pressure and better mental health was observed in individuals who develop hypertension until follow-up. Overall, our findings offer insights on the complex relationship between mental health, blood pressure, and hypertension, suggesting that—via baroreceptor mechanisms and reinforcement learning—the association of higher blood pressure with better mental health may ultimately contribute to the development of hypertension.

Suggested Citation

  • H. Lina Schaare & Maria Blöchl & Deniz Kumral & Marie Uhlig & Lorenz Lemcke & Sofie L. Valk & Arno Villringer, 2023. "Associations between mental health, blood pressure and the development of hypertension," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
  • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37579-6
    DOI: 10.1038/s41467-023-37579-6
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    References listed on IDEAS

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    1. Nikos K. Logothetis, 2008. "What we can do and what we cannot do with fMRI," Nature, Nature, vol. 453(7197), pages 869-878, June.
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