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Development of the oral resistome during the first decade of life

Author

Listed:
  • Smitha Sukumar

    (The University of Sydney)

  • Fang Wang

    (The University of Sydney
    The University of Sydney)

  • Carra A. Simpson

    (University of California, Los Angeles)

  • Cali E. Willet

    (Core Research Facilities, The University of Sydney)

  • Tracy Chew

    (Core Research Facilities, The University of Sydney)

  • Toby E. Hughes

    (The University of Sydney
    University of Adelaide)

  • Michelle R. Bockmann

    (University of Adelaide)

  • Rosemarie Sadsad

    (Core Research Facilities, The University of Sydney)

  • F. Elizabeth Martin

    (The University of Sydney)

  • Henry W. Lydecker

    (Core Research Facilities, The University of Sydney)

  • Gina V. Browne

    (The University of Sydney
    Westmead Centre for Oral Health)

  • Kylie M. Davis

    (University of Adelaide)

  • Minh Bui

    (The University of Melbourne)

  • Elena Martinez

    (The University of Sydney
    Institute of Clinical Pathology and Medical Research, NSW Health Pathology)

  • Christina J. Adler

    (The University of Sydney
    The University of Sydney)

Abstract

Antibiotic overuse has promoted the spread of antimicrobial resistance (AMR) with significant health and economic consequences. Genome sequencing reveals the widespread presence of antimicrobial resistance genes (ARGs) in diverse microbial environments. Hence, surveillance of resistance reservoirs, like the rarely explored oral microbiome, is necessary to combat AMR. Here, we characterise the development of the paediatric oral resistome and investigate its role in dental caries in 221 twin children (124 females and 97 males) sampled at three time points over the first decade of life. From 530 oral metagenomes, we identify 309 ARGs, which significantly cluster by age, with host genetic effects detected from infancy onwards. Our results suggest potential mobilisation of ARGs increases with age as the AMR associated mobile genetic element, Tn916 transposase was co-located with more species and ARGs in older children. We find a depletion of ARGs and species in dental caries compared to health. This trend reverses in restored teeth. Here we show the paediatric oral resistome is an inherent and dynamic component of the oral microbiome, with a potential role in transmission of AMR and dysbiosis.

Suggested Citation

  • Smitha Sukumar & Fang Wang & Carra A. Simpson & Cali E. Willet & Tracy Chew & Toby E. Hughes & Michelle R. Bockmann & Rosemarie Sadsad & F. Elizabeth Martin & Henry W. Lydecker & Gina V. Browne & Kyli, 2023. "Development of the oral resistome during the first decade of life," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36781-w
    DOI: 10.1038/s41467-023-36781-w
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    References listed on IDEAS

    as
    1. Alyssa G. Kent & Albert C. Vill & Qiaojuan Shi & Michael J. Satlin & Ilana Lauren Brito, 2020. "Widespread transfer of mobile antibiotic resistance genes within individual gut microbiomes revealed through bacterial Hi-C," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    2. Huang Lin & Shyamal Das Peddada, 2020. "Analysis of compositions of microbiomes with bias correction," Nature Communications, Nature, vol. 11(1), pages 1-11, December.
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