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Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice

Author

Listed:
  • Huan Sheng

    (Fudan University
    Fudan University)

  • Chao Lei

    (Fudan University)

  • Yu Yuan

    (Fudan University)

  • Yali Fu

    (Fudan University)

  • Dongyang Cui

    (Fudan University)

  • Li Yang

    (Fudan University)

  • Da Shao

    (Fudan University)

  • Zixuan Cao

    (Fudan University)

  • Hao Yang

    (Fudan University)

  • Xinli Guo

    (Fudan University)

  • Chenshan Chu

    (Fudan University)

  • Yaxian Wen

    (Fudan University)

  • Zhangyin Cai

    (Fudan University)

  • Ming Chen

    (Fudan University)

  • Bin Lai

    (Fudan University)

  • Ping Zheng

    (Fudan University
    Medical College of China Three Gorges University)

Abstract

The lateral hypothalamus (LH) is physiologically critical in brain functions. The LH also plays an important role in drug addiction. However, neural circuits underlying LH involvement of drug addiction remain obscure. In the present study,our results showed that in male mice, during context-induced expression of morphine withdrawal memory, LH glutamatergic neurons played an important role; dopamine D1 receptor-expressing medium spiny neurons (D1-MSNs) projecting from the core of nucleus accumbens (NAcC) to the LH were an important upstream circuit to activate LH glutamatergic neurons; D1-MSNs projecting from the NAcC to the LH activated LH glutamatergic neurons through inhibiting LH local gamma-aminobutyric acid (GABA) neurons. These results suggest that disinhibited LH glutamatergic neurons by neural circuits from the NAcC importantly contribute to context-induced the expression of morphine withdrawal memory.

Suggested Citation

  • Huan Sheng & Chao Lei & Yu Yuan & Yali Fu & Dongyang Cui & Li Yang & Da Shao & Zixuan Cao & Hao Yang & Xinli Guo & Chenshan Chu & Yaxian Wen & Zhangyin Cai & Ming Chen & Bin Lai & Ping Zheng, 2023. "Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-022-35758-5
    DOI: 10.1038/s41467-022-35758-5
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    References listed on IDEAS

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