IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-022-35758-5.html
   My bibliography  Save this article

Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice

Author

Listed:
  • Huan Sheng

    (Fudan University
    Fudan University)

  • Chao Lei

    (Fudan University)

  • Yu Yuan

    (Fudan University)

  • Yali Fu

    (Fudan University)

  • Dongyang Cui

    (Fudan University)

  • Li Yang

    (Fudan University)

  • Da Shao

    (Fudan University)

  • Zixuan Cao

    (Fudan University)

  • Hao Yang

    (Fudan University)

  • Xinli Guo

    (Fudan University)

  • Chenshan Chu

    (Fudan University)

  • Yaxian Wen

    (Fudan University)

  • Zhangyin Cai

    (Fudan University)

  • Ming Chen

    (Fudan University)

  • Bin Lai

    (Fudan University)

  • Ping Zheng

    (Fudan University
    Medical College of China Three Gorges University)

Abstract

The lateral hypothalamus (LH) is physiologically critical in brain functions. The LH also plays an important role in drug addiction. However, neural circuits underlying LH involvement of drug addiction remain obscure. In the present study,our results showed that in male mice, during context-induced expression of morphine withdrawal memory, LH glutamatergic neurons played an important role; dopamine D1 receptor-expressing medium spiny neurons (D1-MSNs) projecting from the core of nucleus accumbens (NAcC) to the LH were an important upstream circuit to activate LH glutamatergic neurons; D1-MSNs projecting from the NAcC to the LH activated LH glutamatergic neurons through inhibiting LH local gamma-aminobutyric acid (GABA) neurons. These results suggest that disinhibited LH glutamatergic neurons by neural circuits from the NAcC importantly contribute to context-induced the expression of morphine withdrawal memory.

Suggested Citation

  • Huan Sheng & Chao Lei & Yu Yuan & Yali Fu & Dongyang Cui & Li Yang & Da Shao & Zixuan Cao & Hao Yang & Xinli Guo & Chenshan Chu & Yaxian Wen & Zhangyin Cai & Ming Chen & Bin Lai & Ping Zheng, 2023. "Nucleus accumbens circuit disinhibits lateral hypothalamus glutamatergic neurons contributing to morphine withdrawal memory in male mice," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-022-35758-5
    DOI: 10.1038/s41467-022-35758-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-35758-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-35758-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Yingjie Zhu & Carl F. R. Wienecke & Gregory Nachtrab & Xiaoke Chen, 2016. "A thalamic input to the nucleus accumbens mediates opiate dependence," Nature, Nature, vol. 530(7589), pages 219-222, February.
    2. Glenda C. Harris & Mathieu Wimmer & Gary Aston-Jones, 2005. "A role for lateral hypothalamic orexin neurons in reward seeking," Nature, Nature, vol. 437(7058), pages 556-559, September.
    3. Jiejie Wang & Xinyou Lv & Yu Wu & Tao Xu & Mingfei Jiao & Risheng Yang & Xia Li & Ming Chen & Yinggang Yan & Changwan Chen & Weifan Dong & Wei Yang & Min Zhuo & Tao Chen & Jianhong Luo & Shuang Qiu, 2018. "Postsynaptic RIM1 modulates synaptic function by facilitating membrane delivery of recycling NMDARs in hippocampal neurons," Nature Communications, Nature, vol. 9(1), pages 1-15, December.
    4. Fan Yang & Yunhui Liu & Jie Tu & Jun Wan & Jie Zhang & Bifeng Wu & Shanping Chen & Jiawei Zhou & Yangling Mu & Liping Wang, 2014. "Activated astrocytes enhance the dopaminergic differentiation of stem cells and promote brain repair through bFGF," Nature Communications, Nature, vol. 5(1), pages 1-14, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Hiroyuki Kawai & Youcef Bouchekioua & Naoya Nishitani & Kazuhei Niitani & Shoma Izumi & Hinako Morishita & Chihiro Andoh & Yuma Nagai & Masashi Koda & Masako Hagiwara & Koji Toda & Hisashi Shirakawa &, 2022. "Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    2. Ines Villano & Marco La Marra & Girolamo Di Maio & Vincenzo Monda & Sergio Chieffi & Ezia Guatteo & Giovanni Messina & Fiorenzo Moscatelli & Marcellino Monda & Antonietta Messina, 2022. "Physiological Role of Orexinergic System for Health," IJERPH, MDPI, vol. 19(14), pages 1-18, July.
    3. Kuikui Zhou & Hua Xu & Shanshan Lu & Shaolei Jiang & Guoqiang Hou & Xiaofei Deng & Miao He & Yingjie Zhu, 2022. "Reward and aversion processing by input-defined parallel nucleus accumbens circuits in mice," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    4. Robyn Mary Brown & Jennifer Lynn Short & Andrew John Lawrence, 2010. "Identification of Brain Nuclei Implicated in Cocaine-Primed Reinstatement of Conditioned Place Preference: A Behaviour Dissociable from Sensitization," PLOS ONE, Public Library of Science, vol. 5(12), pages 1-13, December.
    5. Kelsey M. Vollmer & Lisa M. Green & Roger I. Grant & Kion T. Winston & Elizabeth M. Doncheck & Christopher W. Bowen & Jacqueline E. Paniccia & Rachel E. Clarke & Annika Tiller & Preston N. Siegler & B, 2022. "An opioid-gated thalamoaccumbal circuit for the suppression of reward seeking in mice," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Yanjun Sun & Lisa M. Giocomo, 2022. "Neural circuit dynamics of drug-context associative learning in the mouse hippocampus," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    7. Atsushi Noritake & Taihei Ninomiya & Kenta Kobayashi & Masaki Isoda, 2023. "Chemogenetic dissection of a prefrontal-hypothalamic circuit for socially subjective reward valuation in macaques," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    8. Joram D Mul & Susanne E la Fleur & Pim W Toonen & Anthonieke Afrasiab-Middelman & Rob Binnekade & Dustin Schetters & Michel M M Verheij & Robert M Sears & Judith R Homberg & Anton N M Schoffelmeer & R, 2011. "Chronic Loss of Melanin-Concentrating Hormone Affects Motivational Aspects of Feeding in the Rat," PLOS ONE, Public Library of Science, vol. 6(5), pages 1-13, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-022-35758-5. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.