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A self-powered ingestible wireless biosensing system for real-time in situ monitoring of gastrointestinal tract metabolites

Author

Listed:
  • Ernesto De la Paz

    (University of California San Diego)

  • Nikhil Harsha Maganti

    (University of California San Diego)

  • Alexander Trifonov

    (University of California San Diego)

  • Itthipon Jeerapan

    (University of California San Diego)

  • Kuldeep Mahato

    (University of California San Diego)

  • Lu Yin

    (University of California San Diego)

  • Thitaporn Sonsa-ard

    (University of California San Diego)

  • Nicolas Ma

    (University of California San Diego)

  • Won Jung

    (University of California San Diego)

  • Ryan Burns

    (University of California San Diego)

  • Amir Zarrinpar

    (University of California San Diego
    VA San Diego Healthcare System
    University of California San Diego)

  • Joseph Wang

    (University of California San Diego)

  • Patrick P. Mercier

    (University of California San Diego)

Abstract

Information related to the diverse and dynamic metabolite composition of the small intestine is crucial for the diagnosis and treatment of various diseases. However, our current understanding of the physiochemical dynamics of metabolic processes within the small intestine is limited due to the lack of in situ access to the intestinal environment. Here, we report a demonstration of a battery-free ingestible biosensing system for monitoring metabolites in the small intestine. As a proof of concept, we monitor the intestinal glucose dynamics on a porcine model. Battery-free operation is achieved through a self-powered glucose biofuel cell/biosensor integrated into a circuit that performs energy harvesting, biosensing, and wireless telemetry via a power-to-frequency conversion scheme using magnetic human body communication. Such long-term biochemical analysis could potentially provide critical information regarding the complex and dynamic small intestine metabolic profiles.

Suggested Citation

  • Ernesto De la Paz & Nikhil Harsha Maganti & Alexander Trifonov & Itthipon Jeerapan & Kuldeep Mahato & Lu Yin & Thitaporn Sonsa-ard & Nicolas Ma & Won Jung & Ryan Burns & Amir Zarrinpar & Joseph Wang &, 2022. "A self-powered ingestible wireless biosensing system for real-time in situ monitoring of gastrointestinal tract metabolites," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35074-y
    DOI: 10.1038/s41467-022-35074-y
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    References listed on IDEAS

    as
    1. Gavriel Iddan & Gavriel Meron & Arkady Glukhovsky & Paul Swain, 2000. "Wireless capsule endoscopy," Nature, Nature, vol. 405(6785), pages 417-417, May.
    2. Ohad Manor & Chengzhen L. Dai & Sergey A. Kornilov & Brett Smith & Nathan D. Price & Jennifer C. Lovejoy & Sean M. Gibbons & Andrew T. Magis, 2020. "Health and disease markers correlate with gut microbiome composition across thousands of people," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    3. G Traverso & G Ciccarelli & S Schwartz & T Hughes & T Boettcher & R Barman & R Langer & A Swiston, 2015. "Physiologic Status Monitoring via the Gastrointestinal Tract," PLOS ONE, Public Library of Science, vol. 10(11), pages 1-13, November.
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    1. Rong Cai & Chiagoziem Ngwadom & Ravindra Saxena & Jayashree Soman & Chase Bruggeman & David P. Hickey & Rafael Verduzco & Caroline M. Ajo-Franklin, 2024. "Creation of a point-of-care therapeutics sensor using protein engineering, electrochemical sensing and electronic integration," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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