IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-35050-6.html
   My bibliography  Save this article

Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing

Author

Listed:
  • Yun Meng

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
    Fudan University)

  • Lijie Chen

    (Fudan University)

  • Yang Chen

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
    Tongji University)

  • Jieyun Shi

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine)

  • Zheng Zhang

    (East China Normal University)

  • Yiwen Wang

    (East China Normal University)

  • Fan Wu

    (Fudan University)

  • Xingwu Jiang

    (Fudan University)

  • Wei Yang

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine)

  • Li Zhang

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine)

  • Chaochao Wang

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine)

  • Xianfu Meng

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine)

  • Yelin Wu

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine)

  • Wenbo Bu

    (Tongji University Cancer Center, Shanghai Tenth People’s Hospital, Tongji University School of Medicine
    Fudan University)

Abstract

Bacteria and excessive inflammation are two main factors causing non-healing wounds. However, current studies have mainly focused on the inhibition of bacteria survival for wound healing while ignoring the excessive inflammation induced by dead bacteria-released lipopolysaccharide (LPS) or peptidoglycan (PGN). Herein, a boron-trapping strategy has been proposed to prevent both infection and excessive inflammation by synthesizing a class of reactive metal boride nanoparticles (MB NPs). Our results show that the MB NPs are gradually hydrolyzed to generate boron dihydroxy groups and metal cations while generating a local alkaline microenvironment. This microenvironment greatly enhances boron dihydroxy groups to trap LPS or PGN through an esterification reaction, which not only enhances metal cation-induced bacterial death but also inhibits dead bacteria-induced excessive inflammation both in vitro and in vivo, finally accelerating wound healing. Taken together, this boron-trapping strategy provides an approach to the treatment of bacterial infection and the accompanying inflammation.

Suggested Citation

  • Yun Meng & Lijie Chen & Yang Chen & Jieyun Shi & Zheng Zhang & Yiwen Wang & Fan Wu & Xingwu Jiang & Wei Yang & Li Zhang & Chaochao Wang & Xianfu Meng & Yelin Wu & Wenbo Bu, 2022. "Reactive metal boride nanoparticles trap lipopolysaccharide and peptidoglycan for bacteria-infected wound healing," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35050-6
    DOI: 10.1038/s41467-022-35050-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-35050-6
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/s41467-022-35050-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Haohao Dong & Quanju Xiang & Yinghong Gu & Zhongshan Wang & Neil G. Paterson & Phillip J. Stansfeld & Chuan He & Yizheng Zhang & Wenjian Wang & Changjiang Dong, 2014. "Structural basis for outer membrane lipopolysaccharide insertion," Nature, Nature, vol. 511(7507), pages 52-56, July.
    2. Xianli Su & Fan Fu & Yonggao Yan & Gang Zheng & Tao Liang & Qiang Zhang & Xin Cheng & Dongwang Yang & Hang Chi & Xinfeng Tang & Qingjie Zhang & Ctirad Uher, 2014. "Self-propagating high-temperature synthesis for compound thermoelectrics and new criterion for combustion processing," Nature Communications, Nature, vol. 5(1), pages 1-7, December.
    3. Z. L. Shaw & Sruthi Kuriakose & Samuel Cheeseman & Michael D. Dickey & Jan Genzer & Andrew J. Christofferson & Russell J. Crawford & Chris F. McConville & James Chapman & Vi Khanh Truong & Aaron Elbou, 2021. "Antipathogenic properties and applications of low-dimensional materials," Nature Communications, Nature, vol. 12(1), pages 1-19, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Rui Liu & Guangkun Ren & Xing Tan & Yuanhua Lin & Cewen Nan, 2016. "Enhanced Thermoelectric Properties of Cu 3 SbSe 3 -Based Composites with Inclusion Phases," Energies, MDPI, vol. 9(10), pages 1-7, October.
    2. Yuxuan Zhang & You Meng & Liqiang Wang & Changyong Lan & Quan Quan & Wei Wang & Zhengxun Lai & Weijun Wang & Yezhan Li & Di Yin & Dengji Li & Pengshan Xie & Dong Chen & Zhe Yang & SenPo Yip & Yang Lu , 2024. "Pulse irradiation synthesis of metal chalcogenides on flexible substrates for enhanced photothermoelectric performance," Nature Communications, Nature, vol. 15(1), pages 1-9, December.
    3. Yiying Yang & Haoxiang Chen & Robin A. Corey & Violette Morales & Yves Quentin & Carine Froment & Anne Caumont-Sarcos & Cécile Albenne & Odile Burlet-Schiltz & David Ranava & Phillip J. Stansfeld & Ju, 2023. "LptM promotes oxidative maturation of the lipopolysaccharide translocon by substrate binding mimicry," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    4. Mathieu Botte & Dongchun Ni & Stephan Schenck & Iwan Zimmermann & Mohamed Chami & Nicolas Bocquet & Pascal Egloff & Denis Bucher & Matilde Trabuco & Robert K. Y. Cheng & Janine D. Brunner & Markus A. , 2022. "Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation," Nature Communications, Nature, vol. 13(1), pages 1-10, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-35050-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.