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CRY2 interacts with CIS1 to regulate thermosensory flowering via FLM alternative splicing

Author

Listed:
  • Zhiwei Zhao

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Craig Dent

    (Monash University)

  • Huafeng Liang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Junqing Lv

    (Chinese Academy of Sciences
    Henan University)

  • Guandong Shang

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Yawen Liu

    (Chinese Academy of Sciences)

  • Fan Feng

    (Chinese Academy of Sciences)

  • Fei Wang

    (Chinese Academy of Sciences)

  • Junhong Pang

    (Chinese Academy of Sciences
    Hebei Normal University)

  • Xu Li

    (Chinese Academy of Sciences)

  • Libang Ma

    (Chinese Academy of Sciences
    University of Chinese Academy of Sciences)

  • Bing Li

    (Hebei Normal University)

  • Sridevi Sureshkumar

    (Monash University)

  • Jia-Wei Wang

    (Chinese Academy of Sciences)

  • Sureshkumar Balasubramanian

    (Monash University)

  • Hongtao Liu

    (Chinese Academy of Sciences)

Abstract

Cryptochromes (CRYs) are evolutionarily conserved photolyase-like photoreceptors found in almost all species, including mammals. CRYs regulate transcription by modulating the activity of several transcription factors, but whether and how they affect pre-mRNA processing are unknown. Photoperiod and temperature are closely associated seasonal cues that influence reproductive timing in plants. CRYs mediate photoperiod-responsive floral initiation, but it is largely unknown whether and how they are also involved in thermosensory flowering. We establish here that blue light and CRY2 play critical roles in thermosensory flowering in Arabidopsis thaliana by regulating RNA alternative splicing (AS) to affect protein expression and development. CRY2 INTERACTING SPLICING FACTOR 1 (CIS1) interacts with CRY2 in a blue light–dependent manner and promotes CRY2–mediated thermosensory flowering. Blue light, CRYs, and CISs affect transcriptome-wide AS profiles, including those of FLOWERING LOCUS M (FLM), which is critical for temperature modulation of flowering. Moreover, CIS1 binds to the FLM pre-mRNA to regulate its AS, while CRY2 regulates the RNA-binding activity of CIS1. Thus, blue light regulates thermosensory flowering via a CRY2–CIS1–FLM signaling pathway that links flowering responses to both light and ambient temperature.

Suggested Citation

  • Zhiwei Zhao & Craig Dent & Huafeng Liang & Junqing Lv & Guandong Shang & Yawen Liu & Fan Feng & Fei Wang & Junhong Pang & Xu Li & Libang Ma & Bing Li & Sridevi Sureshkumar & Jia-Wei Wang & Sureshkumar, 2022. "CRY2 interacts with CIS1 to regulate thermosensory flowering via FLM alternative splicing," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
  • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34886-2
    DOI: 10.1038/s41467-022-34886-2
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    References listed on IDEAS

    as
    1. Marcelo J. Yanovsky & Steve A. Kay, 2002. "Molecular basis of seasonal time measurement in Arabidopsis," Nature, Nature, vol. 419(6904), pages 308-312, September.
    2. Brian D. Zoltowski & Anand T. Vaidya & Deniz Top & Joanne Widom & Michael W. Young & Brian R. Crane, 2011. "Structure of full-length Drosophila cryptochrome," Nature, Nature, vol. 480(7377), pages 396-399, December.
    3. Weiman Xing & Luca Busino & Thomas R. Hinds & Samuel T. Marionni & Nabiha H. Saifee & Matthew F. Bush & Michele Pagano & Ning Zheng, 2013. "SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket," Nature, Nature, vol. 496(7443), pages 64-68, April.
    4. Livia Merendino & Sabine Guth & Daniel Bilbao & Concepción Martínez & Juan Valcárcel, 1999. "Inhibition of msl-2 splicing by Sex-lethal reveals interaction between U2AF35 and the 3′ splice site AG," Nature, Nature, vol. 402(6763), pages 838-841, December.
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