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Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

Author

Listed:
  • Mírian Romitti

    (Université Libre de Bruxelles (ULB))

  • Adrien Tourneur

    (Université Libre de Bruxelles (ULB))

  • Barbara Faria da Fonseca

    (Université Libre de Bruxelles (ULB))

  • Gilles Doumont

    (Université libre de Bruxelles (ULB))

  • Pierre Gillotay

    (Université Libre de Bruxelles (ULB))

  • Xiao-Hui Liao

    (The University of Chicago)

  • Sema Elif Eski

    (Université Libre de Bruxelles (ULB))

  • Gaetan Simaeys

    (Université libre de Bruxelles (ULB)
    Université libre de Bruxelles (ULB))

  • Laura Chomette

    (Université Libre de Bruxelles (ULB))

  • Helene Lasolle

    (Université Libre de Bruxelles (ULB))

  • Olivier Monestier

    (Université Libre de Bruxelles (ULB))

  • Dominika Figini Kasprzyk

    (Université Libre de Bruxelles (ULB))

  • Vincent Detours

    (Université Libre de Bruxelles (ULB))

  • Sumeet Pal Singh

    (Université Libre de Bruxelles (ULB))

  • Serge Goldman

    (Université libre de Bruxelles (ULB)
    Université libre de Bruxelles (ULB))

  • Samuel Refetoff

    (The University of Chicago
    The University of Chicago)

  • Sabine Costagliola

    (Université Libre de Bruxelles (ULB))

Abstract

The thyroid gland captures iodide in order to synthesize hormones that act on almost all tissues and are essential for normal growth and metabolism. Low plasma levels of thyroid hormones lead to hypothyroidism, which is one of the most common disorder in humans and is not always satisfactorily treated by lifelong hormone replacement. Therefore, in addition to the lack of in vitro tractable models to study human thyroid development, differentiation and maturation, functional human thyroid organoids could pave the way to explore new therapeutic approaches. Here we report the generation of transplantable thyroid organoids derived from human embryonic stem cells capable of restoring plasma thyroid hormone in athyreotic mice as a proof of concept for future therapeutic development.

Suggested Citation

  • Mírian Romitti & Adrien Tourneur & Barbara Faria da Fonseca & Gilles Doumont & Pierre Gillotay & Xiao-Hui Liao & Sema Elif Eski & Gaetan Simaeys & Laura Chomette & Helene Lasolle & Olivier Monestier &, 2022. "Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34776-7
    DOI: 10.1038/s41467-022-34776-7
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    References listed on IDEAS

    as
    1. Siqin Bao & Fuchou Tang & Xihe Li & Katsuhiko Hayashi & Astrid Gillich & Kaiqin Lao & M. Azim Surani, 2009. "Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells," Nature, Nature, vol. 461(7268), pages 1292-1295, October.
    2. Xiaoping Han & Ziming Zhou & Lijiang Fei & Huiyu Sun & Renying Wang & Yao Chen & Haide Chen & Jingjing Wang & Huanna Tang & Wenhao Ge & Yincong Zhou & Fang Ye & Mengmeng Jiang & Junqing Wu & Yanyu Xia, 2020. "Construction of a human cell landscape at single-cell level," Nature, Nature, vol. 581(7808), pages 303-309, May.
    3. Thomas Moreau & Amanda L. Evans & Louella Vasquez & Marloes R. Tijssen & Ying Yan & Matthew W. Trotter & Daniel Howard & Maria Colzani & Meera Arumugam & Wing Han Wu & Amanda Dalby & Riina Lampela & G, 2016. "Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming," Nature Communications, Nature, vol. 7(1), pages 1-16, September.
    4. Francesco Antonica & Dominika Figini Kasprzyk & Robert Opitz & Michelina Iacovino & Xiao-Hui Liao & Alexandra Mihaela Dumitrescu & Samuel Refetoff & Kathelijne Peremans & Mario Manto & Michael Kyba & , 2012. "Generation of functional thyroid from embryonic stem cells," Nature, Nature, vol. 491(7422), pages 66-71, November.
    5. Junyue Cao & Malte Spielmann & Xiaojie Qiu & Xingfan Huang & Daniel M. Ibrahim & Andrew J. Hill & Fan Zhang & Stefan Mundlos & Lena Christiansen & Frank J. Steemers & Cole Trapnell & Jay Shendure, 2019. "The single-cell transcriptional landscape of mammalian organogenesis," Nature, Nature, vol. 566(7745), pages 496-502, February.
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