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Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism

Author

Listed:
  • Mírian Romitti

    (Université Libre de Bruxelles (ULB))

  • Adrien Tourneur

    (Université Libre de Bruxelles (ULB))

  • Barbara Faria da Fonseca

    (Université Libre de Bruxelles (ULB))

  • Gilles Doumont

    (Université libre de Bruxelles (ULB))

  • Pierre Gillotay

    (Université Libre de Bruxelles (ULB))

  • Xiao-Hui Liao

    (The University of Chicago)

  • Sema Elif Eski

    (Université Libre de Bruxelles (ULB))

  • Gaetan Simaeys

    (Université libre de Bruxelles (ULB)
    Université libre de Bruxelles (ULB))

  • Laura Chomette

    (Université Libre de Bruxelles (ULB))

  • Helene Lasolle

    (Université Libre de Bruxelles (ULB))

  • Olivier Monestier

    (Université Libre de Bruxelles (ULB))

  • Dominika Figini Kasprzyk

    (Université Libre de Bruxelles (ULB))

  • Vincent Detours

    (Université Libre de Bruxelles (ULB))

  • Sumeet Pal Singh

    (Université Libre de Bruxelles (ULB))

  • Serge Goldman

    (Université libre de Bruxelles (ULB)
    Université libre de Bruxelles (ULB))

  • Samuel Refetoff

    (The University of Chicago
    The University of Chicago)

  • Sabine Costagliola

    (Université Libre de Bruxelles (ULB))

Abstract

The thyroid gland captures iodide in order to synthesize hormones that act on almost all tissues and are essential for normal growth and metabolism. Low plasma levels of thyroid hormones lead to hypothyroidism, which is one of the most common disorder in humans and is not always satisfactorily treated by lifelong hormone replacement. Therefore, in addition to the lack of in vitro tractable models to study human thyroid development, differentiation and maturation, functional human thyroid organoids could pave the way to explore new therapeutic approaches. Here we report the generation of transplantable thyroid organoids derived from human embryonic stem cells capable of restoring plasma thyroid hormone in athyreotic mice as a proof of concept for future therapeutic development.

Suggested Citation

  • Mírian Romitti & Adrien Tourneur & Barbara Faria da Fonseca & Gilles Doumont & Pierre Gillotay & Xiao-Hui Liao & Sema Elif Eski & Gaetan Simaeys & Laura Chomette & Helene Lasolle & Olivier Monestier &, 2022. "Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-34776-7
    DOI: 10.1038/s41467-022-34776-7
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    References listed on IDEAS

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