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Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells

Author

Listed:
  • Siqin Bao

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK)

  • Fuchou Tang

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK)

  • Xihe Li

    (College of Life Science, Inner Mongolia University/Mengniu RB CO. Ltd., West No. 1 Daxue Road, Huhhot, Inner Mongolia 010021, China)

  • Katsuhiko Hayashi

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK
    Present address: Department of Anatomy and Cell Biology, Graduate School of Medicine, Kyoto University, Yoshida-Konoe-Cho, Sako-Ku, Kyoto 606-8501, Japan.)

  • Astrid Gillich

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK)

  • Kaiqin Lao

    (Molecular Cell Biology, Applied Biosystems, 850 Lincoln Centre Drive, Foster City, California 94404, USA)

  • M. Azim Surani

    (Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge, CB2 1QN, UK)

Abstract

Epiblasts regain pluripotency The pluripotent state, first established in the primitive ectoderm cells of the blastocyst-stage embryo, is lost during subsequent development. Bao et al. now show that advanced post-implantation epiblast cells from mouse embryos aged up to 7.5 days can be reprogrammed back to pluripotency by exposure to LIF/STAT3 signalling. They show accompanying changes in the transcriptome (the total mRNA in the cell) results in a loss of the phenotypic and epigenetic memory found in epiblast cells. Cells reprogrammed in this way can contribute to somatic tissues and germ cells in chimaeras, unlike self-renewing epiblast stem cells. This work provides a model for studying how signalling and epigenetic reprogramming may promote reacquisition of pluripotency.

Suggested Citation

  • Siqin Bao & Fuchou Tang & Xihe Li & Katsuhiko Hayashi & Astrid Gillich & Kaiqin Lao & M. Azim Surani, 2009. "Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells," Nature, Nature, vol. 461(7268), pages 1292-1295, October.
    • Handle: RePEc:nat:nature:v:461:y:2009:i:7268:d:10.1038_nature08534
    DOI: 10.1038/nature08534
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    1. Mírian Romitti & Adrien Tourneur & Barbara Faria da Fonseca & Gilles Doumont & Pierre Gillotay & Xiao-Hui Liao & Sema Elif Eski & Gaetan Simaeys & Laura Chomette & Helene Lasolle & Olivier Monestier &, 2022. "Transplantable human thyroid organoids generated from embryonic stem cells to rescue hypothyroidism," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Shengyong Yu & Chunhua Zhou & Jiangping He & Zhaokai Yao & Xingnan Huang & Bowen Rong & Hong Zhu & Shijie Wang & Shuyan Chen & Xialian Wang & Baomei Cai & Guoqing Zhao & Yuhan Chen & Lizhan Xiao & He , 2022. "BMP4 drives primed to naïve transition through PGC-like state," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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